Weberg R, Berstad K, Berstad A
Department of Medicine, Lovisenberg Hospital, Oslo, Norway.
Eur J Clin Invest. 1990 Oct;20(5):511-5. doi: 10.1111/j.1365-2362.1990.tb01894.x.
In 10 duodenal ulcer patients gastric juice was aspirated every 10 min for 20 min before and 200 min after sham feeding. One antacid tablet or placebo was given 80 min after the sham feeding. Analyses of the aspirates showed that antacids reduced mean hydrogen ion activity and pepsin concentration significantly for 40 and 60 min, respectively, and increased phospholipid concentration for 30 min, compared with placebo. Highest mean pH was 2.52. The percentage of pH readings at or above pH levels of 2, 3, and 4 during the 2 h period following antacid administration was 29, 10, and 2%, respectively. No significant differences between antacid and placebo were found regarding intragastric concentrations of bile acids and prostaglandin E2. When one antacid tablet was administered 80 min after a real meal, the effect on intragastric pH was similarly weak, but lasted slightly longer. Acid neutralization' alone can hardly explain the ulcer-healing effect of low-dose antacids. Antacid-induced increase in intragastric concentration of phospholipids is a new and potentially important observation.
对10名十二指肠溃疡患者，在假饲前20分钟及假饲后200分钟，每10分钟抽吸一次胃液。在假饲80分钟后给予一片抗酸剂或安慰剂。对抽吸物的分析表明，与安慰剂相比，抗酸剂分别使平均氢离子活性和胃蛋白酶浓度显著降低40分钟和60分钟，并使磷脂浓度升高30分钟。最高平均pH值为2.52。在服用抗酸剂后的2小时内，pH值读数在2、3和4及以上水平的百分比分别为29%、10%和2%。在胃内胆汁酸和前列腺素E2浓度方面，抗酸剂与安慰剂之间未发现显著差异。当在实际进食80分钟后服用一片抗酸剂时，对胃内pH值的影响同样微弱，但持续时间稍长。单纯的“酸中和”几乎无法解释小剂量抗酸剂的溃疡愈合作用。抗酸剂引起的胃内磷脂浓度升高是一项新的且可能具有重要意义的观察结果。
