Department of Pediatric Surgery, Hunan Children's Hospital, Changsha, People's Republic of China.
Anticancer Drugs. 2020 Apr;31(4):319-325. doi: 10.1097/CAD.0000000000000899.
Long noncoding RNAs (lncRNAs) are a group of non-protein-coding transcripts exceeding 200 nucleotides in length, which are emerging as key players in various fundamental biological processes. Furthermore, it is increasingly recognized that mutation and dysregulation of lncRNAs contribute importantly to a variety of human diseases, particularly human cancers. Previous studies have revealed that altered lncRNAs have a close association with tumorigenesis, metastasis, prognosis and diagnosis of cancers. The present review aims to exhibit a brief overview of the associated reports of lncRNAs in cancers, including colorectal cancer, gastric cancer, lung adenocarcinoma, nasopharyngeal carcinoma, cervical cancer and esophageal cancer. Altogether, we argue that lncRNAs have potential as new biomarkers in cancer prognosis and diagnosis, and as promising therapeutic targets for the prevention and treatment of human cancers.
长非编码 RNA（lncRNA）是一组长度超过 200 个核苷酸的非蛋白编码转录本，它们正在成为各种基本生物学过程中的关键参与者。此外，人们越来越认识到，lncRNA 的突变和失调对多种人类疾病，特别是人类癌症的发生有重要贡献。先前的研究表明，改变的 lncRNA 与癌症的发生、转移、预后和诊断密切相关。本综述旨在简要概述 lncRNA 在癌症中的相关报道，包括结直肠癌、胃癌、肺腺癌、鼻咽癌、宫颈癌和食管癌。总之，我们认为 lncRNA 有可能成为癌症预后和诊断的新型生物标志物，以及预防和治疗人类癌症的有前途的治疗靶点。
