a Department of Cardiology , Yuncheng County People's Hospital , Heze , China.
b Department of Cardiology , Qilu Hospital of Shandong University , Jinan , China.
Adipocyte. 2019 Dec;8(1):137-143. doi: 10.1080/21623945.2019.1595270. Epub 2019 Mar 24.
Whether adiponectin (ADIPOQ) polymorphisms affect individual susceptibility to coronary artery disease (CAD) remains controversial. Therefore, we performed this meta-analysis to better analyse associations between ADIPOQ polymorphisms and CAD. PubMed, Web of Science, Embase and CNKI were searched for eligible studies. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Totally, 51 studies were eligible for analyses. In overall analyses, significant associations with the susceptibility to CAD were detected for rs266729 (overdominant model: p= 0.03, OR = 1.11, 95% CI 1.01-1.22), rs822395 (recessive model: p= 0.007, OR = 1.21, 95% CI 1.05-1.40) and rs2241766 (dominant model: p= 0.0009, OR = 0.82, 95% CI 0.73-0.92; recessive model: p= 0.04, OR = 1.29, 95% CI 1.02-1.64; allele model: p< 0.0001, OR = 0.80, 95% CI 0.73-0.88) polymorphisms. Further subgroup analyses by ethnicity revealed that rs1501299 polymorphism was significantly associated with the susceptibility to CAD in East Asians, while rs2241766 polymorphism was significantly associated with the susceptibility to CAD in Caucasians, East Asians and South Asians. In summary, our findings indicated that rs266729, rs822395, rs1501299 and rs2241766 polymorphisms were all significantly associated with the susceptibility to CAD in certain populations.
脂联素（ADIPOQ）多态性是否影响个体患冠状动脉疾病（CAD）的易感性仍存在争议。因此，我们进行了这项荟萃分析，以更好地分析 ADIPOQ 多态性与 CAD 之间的关系。我们检索了 PubMed、Web of Science、Embase 和中国知网（CNKI）以获取符合条件的研究。计算了比值比（ORs）和 95%置信区间（CIs）。共有 51 项研究符合分析条件。总体分析显示，rs266729（超显性模型：p=0.03，OR=1.11，95%CI 1.01-1.22）、rs822395（隐性模型：p=0.007，OR=1.21，95%CI 1.05-1.40）和 rs2241766（显性模型：p=0.0009，OR=0.82，95%CI 0.73-0.92；隐性模型：p=0.04，OR=1.29，95%CI 1.02-1.64；等位基因模型：p<0.0001，OR=0.80，95%CI 0.73-0.88）多态性与 CAD 的易感性显著相关。按种族进行的亚组分析显示，rs1501299 多态性与东亚人群 CAD 的易感性显著相关，而 rs2241766 多态性与高加索人、东亚人和南亚人 CAD 的易感性显著相关。总之，我们的研究结果表明，rs266729、rs822395、rs1501299 和 rs2241766 多态性在某些人群中与 CAD 的易感性显著相关。
