Kulseng-Hanssen S, Kristoffersen M
Department of Obstetrics and Gynecology Boerum Hospital, Norway.
Scand J Urol Nephrol Suppl. 1988;114:48-52.
Simultaneous urethrocystometry was performed in 93 females without and 174 patients with neurourological symptoms. Both populations were divided into 3 age groups. The urethral pressure variation (delta MUP) was calculated as the difference between the highest (MUPH) and the lowest maximum urethral pressure (MUPL) observed during one minute. In all age groups, both the highest and the lowest maximum urethral pressure, were significantly higher in the normal females than in the patients during retrograde bladder filling. There was, however, no significant difference in the degree of the urethral pressure variation (delta MUP) between normal females and patients in the different age groups. Typical urethral pressure variation was also observed during physiological bladder filling. Thus, urethral pressure variation in itself is a physiological phenomenon. With less difference between the lowest maximum urethral pressure and the bladder pressure the possibility of leaking urine is increased. A urethral pressure decrease may therefore cause leakage in a patient, but not in a normal female. More than 50% of the normal females had a urethral pressure variation of more than 20 cm H2O. The previous definitions of urethral pressure variations (unstable urethral pressure, urethral instability) which describe the condition as pathologic when the pressure varies more than 10, 15 or 20 cm H2O can therefore not longer be considered useful.
对93名无神经泌尿症状的女性和174名有神经泌尿症状的患者进行了同步尿道膀胱测压。两组人群均分为3个年龄组。尿道压力变化（δMUP）计算为一分钟内观察到的最高最大尿道压力（MUPH）与最低最大尿道压力（MUPL）之间的差值。在所有年龄组中，在逆行膀胱充盈期间，正常女性的最高和最低最大尿道压力均显著高于患者。然而，不同年龄组的正常女性和患者之间的尿道压力变化程度（δMUP）没有显著差异。在生理性膀胱充盈期间也观察到典型的尿道压力变化。因此，尿道压力变化本身是一种生理现象。最低最大尿道压力与膀胱压力之间的差异越小，漏尿的可能性就越大。因此，尿道压力降低可能导致患者漏尿，但正常女性不会。超过50%的正常女性尿道压力变化超过20 cmH₂O。因此，以前将压力变化超过10、15或20 cmH₂O时的尿道压力变化（不稳定尿道压力、尿道不稳定）定义为病理性的定义不再被认为有用。
