Karson C N, Coppola R, Daniel D G, Weinberger D R
Psychiatry Service, VA Medical Center, North Little Rock, AR 72114.
Schizophr Bull. 1988;14(2):193-7. doi: 10.1093/schbul/14.2.193.
Despite advances in the processing and display of electroencephalographic (EEG) data, the utility of this inexpensive and noninvasive technique in the investigation of schizophrenia has not been well established. We studied the resting EEG in 19 medication-free patients with chronic schizophrenia and 21 normal controls. Patients with schizophrenia had increased delta activity which was not specific to the frontal regions. Schizophrenic patients also had increased fast activity, and this increase was left sided for the fast beta frequency. Alpha frequency was reduced (less than 10.2 Hz) in 7 of 16 schizophrenic patients. Moreover, those patients with an alpha frequency reduction had a significantly larger mean cerebral ventricular size. These results indicate that the EEG does detect neurophysiological changes in schizophrenia. Our understanding of these changes may be enhanced by other neuroimaging techniques such as computed tomography.
尽管脑电图（EEG）数据的处理和显示技术取得了进展，但这种廉价且无创的技术在精神分裂症研究中的实用性尚未得到充分确立。我们研究了19名未服用药物的慢性精神分裂症患者和21名正常对照者的静息脑电图。精神分裂症患者的δ活动增加，且并非额叶区域所特有。精神分裂症患者的快速活动也增加，且快速β频率的增加在左侧。16名精神分裂症患者中有7人的α频率降低（低于10.2赫兹）。此外，那些α频率降低的患者平均脑室大小明显更大。这些结果表明脑电图确实能检测出精神分裂症患者的神经生理变化。我们对这些变化的理解可能会通过计算机断层扫描等其他神经影像学技术得到加强。
