Morihisa J M, McAnulty G B
Biol Psychiatry. 1985 Jan;20(1):3-19. doi: 10.1016/0006-3223(85)90131-3.
A computerized topographic technique that maps brain electrical activity is applied to the investigation of neurophysiological abnormalities in medicated and drug-free schizophrenic patients. This topographic approach uses EEG and evoked potentials to provide functional measures of electrophysiological abnormalities. Neurophysiological differences between schizophrenic patients and controls are delineated which add further evidence that frontal lobe dysfunction may be relevant to our understanding of schizophrenia. An initial investigation employs computed tomography to examine the relationship of structural anatomical pathology in schizophrenia with the functional abnormalities that may be defined using brain electrical activity mapping. When schizophrenic patients with and without frontal cortical atrophy were compared, electrophysiological differences were delineated that overlay frontal cortical regions. This preliminary work suggests that in schizophrenia, abnormal electrophysiological function is associated with definable gross morphological abnormalities of the brain.
一种绘制脑电活动图谱的计算机地形学技术被应用于对服用药物和未服用药物的精神分裂症患者神经生理异常的研究。这种地形学方法利用脑电图和诱发电位来提供电生理异常的功能测量。描绘了精神分裂症患者与对照组之间的神经生理差异，这进一步证明额叶功能障碍可能与我们对精神分裂症的理解有关。一项初步研究采用计算机断层扫描来检查精神分裂症的结构解剖病理学与使用脑电活动图谱可能定义的功能异常之间的关系。当比较有和没有额叶皮质萎缩的精神分裂症患者时，描绘出了覆盖额叶皮质区域的电生理差异。这项初步工作表明，在精神分裂症中，异常的电生理功能与可定义的大脑大体形态异常有关。
