Cruickshanks Karen J, Nondahl David M, Fischer Mary E, Schubert Carla R, Tweed Ted S
Department of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin-Madison.
Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin-Madison.
Am J Audiol. 2020 Mar 5;29(1):59-67. doi: 10.1044/2019_AJA-19-00021. Epub 2020 Feb 3.
Purpose Longitudinal population-based cohort data were used to develop a standardized classification system for age-related hearing impairment using thresholds for frequencies (0.5-8 kHz) typically measured in cohort studies. Method Audiometric testing data collected in the Epidemiology of Hearing Loss Study from participants ( = 1,369) with four visits (1993-1995, 1998-2000, 2003-2005, and 2009-2010) were included (10,952 audiograms). Cluster analyses (Wald's method) were used to identify audiometric patterns. Maximum allowable threshold values were defined for each cluster to create an ordered scale. Progression was defined as a two-step change. Results An eight-step scale was developed to capture audiogram shape and severity of hearing impairment. Of the 1,094 participants classified as having normal hearing based on a pure-tone average, only 25% ( = 277) were classified as Level 1 (all thresholds ≤ 20 dB HL) on the new scale, whereas 17% ( = 182) were Levels 4-6. During the 16-year follow-up, 64.9% of those at Level 1 progressed. There was little regression using this scale. Conclusions This is the first scale developed from population-based longitudinal cohort data to capture audiogram shape across time. This simple, standardized scale is easy to apply, reduces misclassification of normal hearing, and may be a useful method for identifying risk factors for early, preclinical, age-related changes in hearing.
基于纵向人群队列数据,利用队列研究中通常测量的频率(0.5 - 8kHz)阈值,开发一种与年龄相关的听力损失标准化分类系统。方法:纳入听力损失流行病学研究中1369名参与者在四次访视(1993 - 1995年、1998 - 2000年、2003 - 2005年和2009 - 2010年)收集的听力测试数据(共10952份听力图)。采用聚类分析(Wald方法)识别听力图模式。为每个聚类定义最大允许阈值以创建一个有序量表。进展定义为两步变化。结果:开发了一个八步量表来描述听力图形状和听力损失严重程度。在基于纯音平均被分类为听力正常的1094名参与者中,在新量表上只有25%(n = 277)被分类为1级(所有阈值≤20dB HL),而17%(n = 182)为4 - 6级。在16年的随访中,1级参与者中有64.9%出现进展。使用该量表几乎没有出现回归情况。结论:这是首个基于人群纵向队列数据开发的量表,用于随时间描述听力图形状。这个简单的标准化量表易于应用,减少了听力正常的误分类,可能是识别听力早期、临床前、与年龄相关变化的危险因素的有用方法。