Liira J, Riihimäki V, Engström K, Pfäffli P
Lappeenranta Regional Institute of Occupational Health, Finland.
Scand J Work Environ Health. 1988 Oct;14(5):322-7. doi: 10.5271/sjweh.1912.
In a study of the kinetics and metabolic interaction of xylene and methyl ethyl ketone (MEK) eight male volunteers were exposed to m-xylene (100 ppm) and MEK (200 ppm). The exposures to the two compounds were carried out both separately and in combination. Respiratory uptake and blood concentration, as well as urinary metabolites (methyl hippuric acid and 2,3-butanediol), were monitored. Coexposure to xylene and MEK resulted in inhibited xylene metabolism. The xylene concentration in blood increased significantly, and the urinary excretion of methyl hippuric acid decreased. The combined exposure did not cause any change in the concentration of MEK in the blood or the excretion of 2,3-butanediol in the urine. Exposure to MEK 20 h before the m-xylene exposure had no detectable effect on the kinetics of m-xylene.
在一项关于二甲苯和甲乙酮（MEK）的动力学及代谢相互作用的研究中，8名男性志愿者暴露于间二甲苯（100 ppm）和MEK（200 ppm）环境中。两种化合物的暴露分别进行，也有联合暴露。监测了呼吸摄取量、血液浓度以及尿液代谢物（甲基马尿酸和2,3 - 丁二醇）。二甲苯和MEK共同暴露导致二甲苯代谢受到抑制。血液中的二甲苯浓度显著升高，甲基马尿酸的尿排泄量减少。联合暴露并未使血液中MEK的浓度或尿液中2,3 - 丁二醇的排泄量发生任何变化。在间二甲苯暴露前20小时暴露于MEK，对间二甲苯的动力学没有可检测到的影响。
