Hardy C, Wang Y, Collier B, Tavassoli M
Veterans Administration Medical Center, Jackson, MS 39216.
Scanning Microsc. 1988 Sep;2(3):1587-91.
Lewis lung carcinoma of C57Bl/6 mice causes a progressive anemia with reticulocytosis and splenomegaly, metastasizes to lungs, liver, and kidneys but does not invade hemopoietic tissues. The cause of this anemia is uncertain. We studied the structure of spleen and bone marrow in these tumor hosts by light and electron microscopy. Splenic congestion of the red pulp with numerous erythropoietic islands and marrow hyperplasia characterized the hemopoietic tissues of these mice, which, when coupled with other hematological parameters suggested a hemolytic condition. However, the erythropoietic response appeared to be in part ineffective as evidenced by phagocytosis of immature as well as mature red blood cells within the spleen and marrow. Thus, the condition of anemia in Lewis lung carcinoma may result from a multifactorial response of hemolysis and ineffective erythropoiesis and hemolysis.
C57Bl/6小鼠的Lewis肺癌会导致进行性贫血，并伴有网织红细胞增多和脾肿大，可转移至肺、肝和肾，但不侵犯造血组织。这种贫血的病因尚不确定。我们通过光学显微镜和电子显微镜研究了这些肿瘤宿主的脾脏和骨髓结构。这些小鼠的造血组织特征为脾红髓充血，有大量红细胞生成岛以及骨髓增生，再结合其他血液学参数提示存在溶血情况。然而，红细胞生成反应似乎部分无效，脾脏和骨髓内不成熟以及成熟红细胞的吞噬现象就是证据。因此，Lewis肺癌中的贫血状况可能是溶血、无效红细胞生成和溶血的多因素反应导致的。
