Inter-University Laboratory of Human Movement Biology, University Claude Bernard Lyon 1, University of Lyon, Lyon, France.
Department of Cancer and Environment, Léon Bérard Cancer Center, Lyon, France.
JMIR Mhealth Uhealth. 2020 Jan 28;8(1):e12306. doi: 10.2196/12306.
There is limited knowledge regarding the potential benefits of physical activity in patients with metastatic breast cancer.
The Advanced stage Breast cancer and Lifestyle Exercise (ABLE) Trial aimed to assess the feasibility of a physical activity intervention in women with metastatic breast cancer and to explore the effects of physical activity on functional, psychological, and clinical parameters.
The ABLE Trial was a single-arm, 6-month intervention study with a home-based, unsupervised, and personalized walking program using an activity tracker. At baseline and 6 months, we assessed anthropometrics, functional fitness, physical activity level, sedentary behavior, quality of life, fatigue, and tumor progression. Paired proportions were compared using the McNemar test and changes of parameters during the intervention were analyzed using the Wilcoxon signed-rank test, the Mann-Whitney test, and Spearman rank correlations.
Overall, 49 participants (mean age 55 years; recruitment rate 94%) were enrolled and 96% adhered to the exercise prescription (attrition rate 2%). Statistically significant improvements in the 6-minute walking distance test (+7%, P<.001) and isometric quadriceps strength (+22%, P<.001), as well as decreases in body mass index (-2.5%, P=.03) and hip circumference (-4.0%, P<.001) were observed at 6 months. Quality of life remained stable and a nonstatistically significant decrease (-16%, P=.07) in fatigue was observed.
The high recruitment and adherence rates suggest the willingness of patients with metastatic breast cancer to participate in a physical activity program. The beneficial outcomes regarding physical fitness and anthropometry of this unsupervised physical activity program may encourage these patients to maintain a physically active lifestyle. Future randomized controlled trials with larger sample sizes are warranted.
ClinicalTrials.gov NCT03148886; https://clinicaltrials.gov/ct2/show/NCT03148886.
对于转移性乳腺癌患者，体力活动的潜在益处知之甚少。
晚期乳腺癌与生活方式锻炼（ABLE）试验旨在评估对转移性乳腺癌患者进行体力活动干预的可行性，并探讨体力活动对功能、心理和临床参数的影响。
ABLE 试验是一项单臂、6 个月的干预研究，采用基于家庭、非监督和个性化的步行计划，使用活动追踪器。在基线和 6 个月时，我们评估了人体测量学、功能健身、体力活动水平、久坐行为、生活质量、疲劳和肿瘤进展情况。使用 McNemar 检验比较配对比例，使用 Wilcoxon 符号秩检验、Mann-Whitney 检验和 Spearman 秩相关分析干预期间参数的变化。
总体而言，招募了 49 名参与者（平均年龄 55 岁；招募率 94%），96%的人坚持了运动处方（失访率 2%）。6 分钟步行距离测试（+7%，P<.001）和等长股四头肌力量（+22%，P<.001）显著改善，体重指数（-2.5%，P=.03）和臀围（-4.0%，P<.001）在 6 个月时也有所下降。生活质量保持稳定，疲劳感略有下降（-16%，P=.07）。
高招募率和参与率表明转移性乳腺癌患者愿意参加体力活动计划。该非监督体力活动计划在体能和人体测量方面的有益结果可能会鼓励这些患者保持积极的生活方式。未来需要更大样本量的随机对照试验。
ClinicalTrials.gov NCT03148886；https://clinicaltrials.gov/ct2/show/NCT03148886。
