ENT Department, West Suffolk Hospital, Hardwick Lane, Bury St Edmunds, UK.
Yale School of Public Health, New Haven, CT, USA.
Eur J Immunol. 2020 Mar;50(3):418-425. doi: 10.1002/eji.201948300. Epub 2020 Feb 10.
To investigate the role of lymphotoxin (LT) in Sjögren's syndrome (SS) and in mucosal associated lymphoid tissue (MALT)-lymphoma, we made transgenic mice (Amy1-LTαβ) that targeted LTα and LTβ to the salivary and lacrimal glands. Amy1-LTαβ mice developed atrophic salivary and lacrimal glands that contained tertiary lymphoid organs (TLOs) and had reduced tear production. Amy1-LTαβ mice developed cervical lymphadenopathy but not MALT-lymphoma. TLO formation in the salivary and lacrimal glands of Amy1-LTαβ was not sufficient to induce autoimmunity as measured by autoantibody titres.
为了研究淋巴毒素 (LT) 在干燥综合征 (SS) 和黏膜相关淋巴组织 (MALT) -淋巴瘤中的作用，我们制作了靶向 LTα 和 LTβ 到唾液腺和泪腺的转基因小鼠 (Amy1-LTαβ)。Amy1-LTαβ 小鼠出现了萎缩的唾液腺和泪腺，其中包含三级淋巴器官 (TLO)，并且泪液生成减少。Amy1-LTαβ 小鼠出现了颈部淋巴结病，但没有 MALT-淋巴瘤。Amy1-LTαβ 小鼠的唾液腺和泪腺中 TLO 的形成不足以诱导自身免疫，这可以通过自身抗体滴度来衡量。
