Jacob Alexander, He Jing, Peck Ammon, Jamil Ali, Bunya Vatinee, Alexander Jessy J, Ambrus Julian L
Department of Medicine, SUNY at Buffalo School of Medicine, Buffalo, NY, USA.
Department of Rheumatology and Immunology, Peking University People's Hospital Beijing China, Beijing, China.
Heliyon. 2024 Dec 11;11(1):e41082. doi: 10.1016/j.heliyon.2024.e41082. eCollection 2025 Jan 15.
Sjögren's (SS) involves salivary and lacrimal gland dysfunction. These studies examined metabolic profiles in the B6. transgene mouse model of SS and a cohort of human SS patients at different stages of disease. In B6. mice, products of glucose and fatty acid were common at 6 months of age, while products of amino acid metabolism were common at 12 months of age. Treating B6. mice with the glycolysis inhibitor 2-deoxyglucose from 6 to 10 months of age normalized salivary gland secretions, dacryoadenitis, hypergammaglobulinemia and physical performance, while treatment from 10 to 14 months of age failed to improve any of the clinical manifestations. Similarly, SS patients at an early stage of disease showed high glycolysis. SS patients with long-standing disease utilized predominantly amino acid metabolism, like B6. mice at 10-12 months of age. Additional studies are suggested to further define metabolic activities at the various disease stages.
干燥综合征（SS）涉及唾液腺和泪腺功能障碍。这些研究检测了SS的B6转基因小鼠模型以及一组处于疾病不同阶段的人类SS患者的代谢谱。在B6小鼠中，葡萄糖和脂肪酸的产物在6月龄时常见，而氨基酸代谢产物在12月龄时常见。在6至10月龄用糖酵解抑制剂2-脱氧葡萄糖治疗B6小鼠可使唾液腺分泌、泪腺炎、高球蛋白血症和身体机能恢复正常，而在10至14月龄进行治疗则未能改善任何临床表现。同样，疾病早期的SS患者表现出高糖酵解。病程较长的SS患者主要利用氨基酸代谢，类似于10至12月龄的B6小鼠。建议进行更多研究以进一步明确不同疾病阶段的代谢活动。
