Lytvynenko Oleksandr O, Konovalenko Volodymyr F, Ryzhov Anton Yu.
Wiad Lek. 2019 Aug 31;72(8):1523-1526.
The treatment of patients with malignant fibrous histiocytoma as well as other soft tissue sarcomas is not sufficiently effective up to date, and has largely changed and reflects the alterations, occurred in oncology as a whole. The number of amputation decreased over the last 10-15 years. Some researchers associate the improvement of treatment outcomes with the development of combined and complex methods. The aim of the study is an improvement of the results of treatment of patients with soft tissue malignant histiocytoma on the basis of determination of factors, influencing local recurrence development.
The basis of our study was a comprehensive analysis of examination and treatment results of 130 patients with MFH of the soft tissue of limbs, of them in 84 patients (64.6%) the recurrences developed. The group included 45 (53.6%) males and 39 (46.4%) females. The major part of patients – 82.1% (60 patients) wereolder than 40 years.
Results and conclusions: The number of recurrences after the treatment in general surgical facilities is 86.9%, whereas in the patients after the treatment in the specialized oncological facilities this figure is twice lower (40%). The characteristic of the medical facility where the patient receives his/her primary treatment largely affects the development of local recurrences, patients’ quality of life and overall survival rates. The surgical method remains the leading modality in the treatment of MFH of ST. Wide and radical excision of tumors in the specialized oncological facilities allows achieving better survival outcomes of the patients.
目前，恶性纤维组织细胞瘤以及其他软组织肉瘤患者的治疗效果仍不够理想，且已发生了很大变化，反映出整个肿瘤学领域的变革。在过去10至15年中，截肢手术的数量有所减少。一些研究人员将治疗效果的改善与联合及综合治疗方法的发展联系起来。本研究的目的是在确定影响局部复发发展的因素的基础上，改善软组织恶性组织细胞瘤患者的治疗效果。
我们的研究基于对130例肢体软组织恶性纤维组织细胞瘤患者的检查和治疗结果进行综合分析，其中84例（64.6%）出现了复发。该组包括45例（53.6%）男性和39例（46.4%）女性。大部分患者（82.1%，即60例）年龄超过40岁。
结果与结论：在普通外科机构接受治疗后的复发率为86.9%，而在专门的肿瘤机构接受治疗的患者中，这一数字低两倍（40%）。患者接受初次治疗的医疗机构的特点在很大程度上影响局部复发的发生、患者的生活质量和总体生存率。手术方法仍然是软组织恶性纤维组织细胞瘤治疗的主要方式。在专门的肿瘤机构广泛彻底切除肿瘤可使患者获得更好的生存结果。
