Department of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy.
Multidisciplinary Department of Medical-Surgical and Dental Specialties, Second University of Naples, 80100 Naples, Italy.
Int J Environ Res Public Health. 2020 Feb 23;17(4):1426. doi: 10.3390/ijerph17041426.
Malignant fibrous histiocytoma is one of the most common soft tissue sarcomas in adults. It occurs only occasionally in oral soft tissues, and knowledge about its characteristics is based on a limited number of cases reported in the literature. Malignant fibrous histiocytoma belongs to the group of soft tissue sarcomas and makes up less than 10% of soft tissue sarcomas. For therapeutic purposes, complete exeresis of the lesion (macroscopic and microscopic) is performed because they have frequent recurrences. As for complementary therapy in addition to surgery, neither radiotherapy nor chemotherapy have been shown to reduce the risk of death related to the disease. Often patients complain of a swelling that grows in a short period of time. It is quite common for patients to report trauma in the area, which is not the cause, but rather the event that allows diagnosis. The mass usually does not cause pain unless it compresses an adjacent nerve structure. The aim of this study is to systematically review the scientific literature in order to identify the most recent studies concerning malignant fibrous histiocytomas localized in oral soft tissues and report their main data. The main outcomes of this study concern the immunohistochemical, molecular, and clinical aspects of this pathology. A systematic review of articles in the electronic databases pubmed, Scopus, and Web of Science was performed. After the selection process, 11 studies met the inclusion criteria and were included in the review. The mean age of the patients was 50.8 years old. The lesions affected various parts of the oral cavity, showing predominantly storiform-pleomorphic patterns. All cases except one were treated with surgical resection and radiation therapy. Although some data emerged from this review, they remain limited to a few case reports. Further studies are necessary in order to standardize the approach to patients affected by oral malignant fibrous histiocytoma (MFH).
恶性纤维组织细胞瘤是成人中最常见的软组织肉瘤之一。它仅偶尔发生在口腔软组织中，对其特征的了解基于文献中报道的有限数量的病例。恶性纤维组织细胞瘤属于软组织肉瘤组，占软组织肉瘤的不到 10%。为了治疗目的，对病变（宏观和微观）进行完全切除，因为它们经常复发。作为手术之外的补充治疗，放射治疗和化学治疗都没有显示出降低与疾病相关的死亡风险。患者经常抱怨在短时间内生长的肿胀。患者报告该区域有创伤很常见，但这不是原因，而是允许诊断的事件。除非肿块压迫邻近的神经结构，否则肿块通常不会引起疼痛。本研究的目的是系统地回顾科学文献，以确定有关口腔软组织中局部恶性纤维组织细胞瘤的最新研究，并报告其主要数据。本研究的主要结果涉及该病理学的免疫组织化学、分子和临床方面。在电子数据库 pubmed、Scopus 和 Web of Science 中进行了文章的系统回顾。经过选择过程，有 11 项研究符合纳入标准并被纳入综述。患者的平均年龄为 50.8 岁。病变影响口腔的各个部位，主要表现为梭形-多形性模式。除了一个病例，所有病例均接受了手术切除和放射治疗。尽管从这次审查中得出了一些数据，但它们仍然仅限于少数病例报告。为了规范受口腔恶性纤维组织细胞瘤（MFH）影响的患者的治疗方法，还需要进一步的研究。
