Sider D, Wilson W G, Sudduth K, Atkin J F, Kelly T E
Department of Pediatrics, University of Virginia Medical Center, Charlottesville 22908.
South Med J. 1988 Dec;81(12):1521-4. doi: 10.1097/00007611-198812000-00014.
We reviewed the results of lymphocyte karyotypes from 232 couples who had had two or more pregnancy losses (spontaneous abortions or stillbirths). Despite the use of strict criteria to correct for possible bias of ascertainment, 8% of these couples (19 of 232) had a chromosome abnormality. Six of these abnormalities were low-percentage mosaicism for aneuploidy or a translocation. If these couples were excluded, 13 (6%) of the study couples had a chromosome abnormality. There was no significant difference in the incidence of chromosome abnormalities in those couples having two losses as compared with those having three or more losses. The study couples were referred from a wide range of sources, and most women had not had extensive gynecologic evaluation. These results confirm the importance of cytogenetic analysis of couples with recurrent pregnancy loss, and suggest that such studies be considered after two losses.
我们回顾了232对有两次或更多次妊娠丢失（自然流产或死产）的夫妇的淋巴细胞核型结果。尽管使用了严格的标准来校正可能的确诊偏倚，但这些夫妇中有8%（232对中的19对）存在染色体异常。其中6种异常为非整倍体或易位的低比例嵌合体。如果排除这些夫妇，研究中的夫妇有13对（6%）存在染色体异常。有两次妊娠丢失的夫妇与有三次或更多次妊娠丢失的夫妇相比，染色体异常的发生率没有显著差异。研究中的夫妇来自广泛的来源，大多数女性没有接受过广泛的妇科评估。这些结果证实了对复发性妊娠丢失夫妇进行细胞遗传学分析的重要性，并建议在两次妊娠丢失后考虑进行此类研究。
