Ayed Wiem, Messaoudi Islem, Belghith Zouhour, Hammami Wajih, Chemkhi Imen, Abidli Nabila, Guermani Helmy, Obay Rim, Amouri Ahlem
Department of Histology and Cytogenetics, Institut Pasteur de Tunis, Tunisie.
Faculty of Medecine of Tunis, University of Tunis El Manar, Tunisia.
Pan Afr Med J. 2017 Sep 29;28:99. doi: 10.11604/pamj.2017.28.99.11879. eCollection 2017.
Recurrent miscarriage (RM) is defined as three or more consecutive pregnancy losses before 24 weeks of gestation. Parental chromosomal abnormalities represent an important etiology of RM. The aim of the present study was to identify the distribution of chromosome abnormalities among Tunisian couples with RM referred to the Department of Cytogenetic at the Pasteur Institute of Tunis (Tunisia) during the last five years. Standard cytogenetic analysis was carried out in a total of 163 couples presenting with two or more spontaneous abortions. Karyotypes were analyzed by R-banding. We identified 14 chromosomal abnormalities including autosomal reciprocal translocation, Robertsonian translocation, inversion, mosaic aneuploidy and heteromorphysm. The overall prevalence of chromosomal abnormalities was 8.5% in our cohort. This finding underlies the importance of cytogenetic investigations in the routine management of RM.
复发性流产（RM）的定义为妊娠24周前连续发生三次或三次以上的妊娠丢失。亲代染色体异常是RM的一个重要病因。本研究的目的是确定过去五年中转诊至突尼斯巴斯德研究所细胞遗传学系的突尼斯RM夫妇中染色体异常的分布情况。对总共163对有两次或两次以上自然流产的夫妇进行了标准细胞遗传学分析。通过R显带分析核型。我们鉴定出14种染色体异常，包括常染色体相互易位、罗伯逊易位、倒位、嵌合非整倍体和异形性。在我们的队列中，染色体异常的总体患病率为8.5%。这一发现凸显了细胞遗传学检查在RM常规管理中的重要性。
