Department of Chemistry, College of Sciences , Northeastern University , Box 332, Shenyang 110819 , China.
Department of Physics , University of Texas at Arlington , Arlington , Texas 76019 , United States.
ACS Appl Mater Interfaces. 2020 Feb 26;12(8):9000-9007. doi: 10.1021/acsami.9b21292. Epub 2020 Feb 17.
A novel hybrid drug nanocarrier is developed with CuCoS nanoparticles as the core to be encapsulated by poly(ionic liquid) (PIL), that is, poly(tetrabutylphosphonium styrenesulfonate) (P[P][SS]), as the shell. Doxorubicin (DOX) is loaded onto the PIL shell via electrostatic attraction involving amine in DOX and styrenesulfonate in PIL. pH- and thermal-responsive characteristics of P[P][SS] endow the multifunctional hybrid nanocarrier system DOX-CuCoS@PIL with sensitive dual-stimuli-triggered drug release behaviors. The CuCoS core converts near-infrared (NIR) irradiation into thermal energy to trigger the shrinkage of the PIL shell, which subsequently promotes drug release, and the pH-responsive release of DOX involves pH-sensitive electrostatic interaction of the PIL shell with DOX. A favorable controlled release of 90.5% is achieved under pH/thermo dual stimuli. In vitro experiments with MCF-7 cells well demonstrated that the drug release is controlled by the acidic intracellular environment with NIR irradiation. The CuCoS core also serves as a photoacoustic (PA) imaging contrast agent, as demonstrated by in vivo treatment of the MCF-7-carrying mice.
一种新型的杂化药物纳米载体被开发出来，以 CuCoS 纳米粒子为核，被聚（离子液体）（PIL），即聚（四丁基膦苯乙烯磺酸盐）（P[P][SS]）包裹。阿霉素（DOX）通过静电吸引负载到 PIL 壳上，涉及 DOX 中的胺和 PIL 中的苯乙烯磺酸盐。P[P][SS]的 pH 和热响应特性赋予多功能杂化纳米载体系统 DOX-CuCoS@PIL 具有敏感的双重刺激触发药物释放行为。CuCoS 核将近红外（NIR）辐射转化为热能，引发 PIL 壳的收缩，从而促进药物释放，而 DOX 的 pH 响应释放涉及 PIL 壳与 DOX 之间 pH 敏感的静电相互作用。在 pH/热双重刺激下，实现了 90.5%的良好控制释放。MCF-7 细胞的体外实验很好地证明了药物释放是由酸性细胞内环境和近红外辐射控制的。CuCoS 核还可用作光声（PA）成像造影剂，通过携带 MCF-7 的小鼠的体内治疗得到证明。
