Butowska Kamila, Woziwodzka Anna, Borowik Agnieszka, Piosik Jacek
Laboratory of Biophysics, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Abrahama 58, 80-307 Gdańsk, Poland.
Aging and Metabolism Research Program, Oklahoma Medical Research Foundation (OMRF), Oklahoma City, OK 73104, USA.
Materials (Basel). 2021 Apr 22;14(9):2135. doi: 10.3390/ma14092135.
Doxorubicin, a member of the anthracycline family, is a common anticancer agent often used as a first line treatment for the wide spectrum of cancers. Doxorubicin-based chemotherapy, although effective, is associated with serious side effects, such as irreversible cardiotoxicity or nephrotoxicity. Those often life-threatening adverse risks, responsible for the elongation of the patients' recuperation period and increasing medical expenses, have prompted the need for creating novel and safer drug delivery systems. Among many proposed concepts, polymeric nanocarriers are shown to be a promising approach, allowing for controlled and selective drug delivery, simultaneously enhancing its activity towards cancerous cells and reducing toxic effects on healthy tissues. This article is a chronological examination of the history of the work progress on polymeric nanostructures, designed as efficient doxorubicin nanocarriers, with the emphasis on the main achievements of 2010-2020. Numerous publications have been reviewed to provide an essential summation of the nanopolymer types and their essential properties, mechanisms towards efficient drug delivery, as well as active targeting stimuli-responsive strategies that are currently utilized in the doxorubicin transportation field.
阿霉素是蒽环类药物家族的一员，是一种常见的抗癌药物，常用于多种癌症的一线治疗。基于阿霉素的化疗虽然有效，但会产生严重的副作用，如不可逆的心脏毒性或肾毒性。这些往往危及生命的不良风险，延长了患者的康复期并增加了医疗费用，促使人们需要开发新型、更安全的药物递送系统。在众多提出的概念中，聚合物纳米载体被证明是一种很有前景的方法，它能够实现药物的可控和选择性递送，同时增强其对癌细胞的活性并降低对健康组织的毒性作用。本文按时间顺序回顾了作为高效阿霉素纳米载体的聚合物纳米结构的研究进展历史，重点介绍了2010年至2020年的主要成果。查阅了大量文献，以对纳米聚合物类型及其基本特性、高效药物递送机制，以及目前在阿霉素运输领域使用的主动靶向刺激响应策略进行必要的总结。
