Inhalation Consultancy Ltd, Leeds, UK.
Department of Experimental and Clinical Medicine, Careggi University Hospital, Florence, Italy.
Expert Rev Respir Med. 2020 Apr;14(4):345-351. doi: 10.1080/17476348.2020.1721286. Epub 2020 Feb 4.
: Inhaled therapies are likely to continue to dominate asthma and chronic obstructive pulmonary disease treatment. Dry powder inhalers (DPIs) have several advantages over pressurized metered-dose inhaler (pMDIs), that are most frequently marketed world-wide, but often difficult to use. This literature search focus on DPI features, with respect to Easyhaler, that may affect their use and patients' clinical benefit.: DPIs are breath-actuated, easy to use, convenient to use, and more environmentally friendly. During inhalation, the formulation in a DPI is disaggregated by a turbulent airflow energy to generate particles with the greatest likelihood of deposition into the airways. The resistance among DPIs varies from low to high and those with high resistance are wrongly considered as difficult to use. Multidose reservoir-type DPIs have been developed to efficiently deliver a wide range of medications, including the fixed-dose combination of budesonide and formoterol. Easyhaler® shares a similar shape with pMDIs and, as other DPIs, its performance is unaffected by environmental and storage conditions. Due to Easyhaler internal design, dose emission is consistent irrespective of the inhalation flow used by each patient.: Easyhaler® may be considered one of the most convenient inhalers, for daily use, in patients with asthma or COPD.
吸入疗法可能继续主导哮喘和慢性阻塞性肺疾病的治疗。干粉吸入器(DPI)相对于最常在全球市场销售的压力定量吸入器(pMDI)具有许多优势,但通常难以使用。本文献检索重点介绍了 DPI 的特性,涉及可能影响其使用和患者临床获益的 Easyhaler。
DPI 是靠气流驱动的,使用方便、方便,而且更环保。在吸入过程中,DPI 中的配方通过湍流气流能量分散,产生最有可能沉积在气道中的颗粒。DPI 之间的阻力从低到高不等,那些阻力高的被错误地认为难以使用。已经开发出多剂量储库型 DPI 以有效输送各种药物,包括布地奈德和福莫特罗的固定剂量组合。Easyhaler®与 pMDI 形状相似,与其他 DPI 一样,其性能不受环境和储存条件的影响。由于 Easyhaler 的内部设计,剂量释放与每个患者使用的吸入气流无关,保持一致。
Easyhaler®可被认为是哮喘或 COPD 患者日常使用最方便的吸入器之一。
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