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易纳器干粉吸入器的特点有利于患者的管理。

The dry powder inhaler features of the Easyhaler that benefit the management of patients.

机构信息

Inhalation Consultancy Ltd, Leeds, UK.

Department of Experimental and Clinical Medicine, Careggi University Hospital, Florence, Italy.

出版信息

Expert Rev Respir Med. 2020 Apr;14(4):345-351. doi: 10.1080/17476348.2020.1721286. Epub 2020 Feb 4.


DOI:10.1080/17476348.2020.1721286
PMID:32013627
Abstract

: Inhaled therapies are likely to continue to dominate asthma and chronic obstructive pulmonary disease treatment. Dry powder inhalers (DPIs) have several advantages over pressurized metered-dose inhaler (pMDIs), that are most frequently marketed world-wide, but often difficult to use. This literature search focus on DPI features, with respect to Easyhaler, that may affect their use and patients' clinical benefit.: DPIs are breath-actuated, easy to use, convenient to use, and more environmentally friendly. During inhalation, the formulation in a DPI is disaggregated by a turbulent airflow energy to generate particles with the greatest likelihood of deposition into the airways. The resistance among DPIs varies from low to high and those with high resistance are wrongly considered as difficult to use. Multidose reservoir-type DPIs have been developed to efficiently deliver a wide range of medications, including the fixed-dose combination of budesonide and formoterol. Easyhaler® shares a similar shape with pMDIs and, as other DPIs, its performance is unaffected by environmental and storage conditions. Due to Easyhaler internal design, dose emission is consistent irrespective of the inhalation flow used by each patient.: Easyhaler® may be considered one of the most convenient inhalers, for daily use, in patients with asthma or COPD.

摘要

吸入疗法可能继续主导哮喘和慢性阻塞性肺疾病的治疗。干粉吸入器(DPI)相对于最常在全球市场销售的压力定量吸入器(pMDI)具有许多优势,但通常难以使用。本文献检索重点介绍了 DPI 的特性,涉及可能影响其使用和患者临床获益的 Easyhaler。

DPI 是靠气流驱动的,使用方便、方便,而且更环保。在吸入过程中,DPI 中的配方通过湍流气流能量分散,产生最有可能沉积在气道中的颗粒。DPI 之间的阻力从低到高不等,那些阻力高的被错误地认为难以使用。已经开发出多剂量储库型 DPI 以有效输送各种药物,包括布地奈德和福莫特罗的固定剂量组合。Easyhaler®与 pMDI 形状相似,与其他 DPI 一样,其性能不受环境和储存条件的影响。由于 Easyhaler 的内部设计,剂量释放与每个患者使用的吸入气流无关,保持一致。

Easyhaler®可被认为是哮喘或 COPD 患者日常使用最方便的吸入器之一。

相似文献

[1]
The dry powder inhaler features of the Easyhaler that benefit the management of patients.

Expert Rev Respir Med. 2020-4

[2]
Easyhaler: an overview of an inhaler device for day-to-day use in patients with asthma and chronic obstructive pulmonary disease.

Drugs Context. 2019-6-5

[3]
Real-life budesonide and formoterol dose emission from the medium and high strength fixed dosed combinations in a Spiromax® dry powder inhaler using inhalation profiles from patients with chronic obstructive pulmonary disease.

Eur J Pharm Sci. 2019-8-28

[4]
Budesonide + formoterol delivered via Spiromax for the management of asthma and COPD: The potential impact on unscheduled healthcare costs of improving inhalation technique compared with Turbuhaler.

Respir Med. 2017-8

[5]
Effect of budesonide/formoterol pressurized metered-dose inhaler on exacerbations versus formoterol in chronic obstructive pulmonary disease: The 6-month, randomized RISE (Revealing the Impact of Symbicort in reducing Exacerbations in COPD) study.

Respir Med. 2017-9-5

[6]
Difference in resistance to humidity between commonly used dry powder inhalers: an in vitro study.

NPJ Prim Care Respir Med. 2016-11-17

[7]
Salbutamol Easyhaler provides non-inferior relief of methacholine induced bronchoconstriction in comparison to Ventoline Evohaler with spacer: A randomized trial.

Respir Med. 2024

[8]
The economic burden of asthma and chronic obstructive pulmonary disease and the impact of poor inhalation technique with commonly prescribed dry powder inhalers in three European countries.

BMC Health Serv Res. 2016-7-12

[9]
Equivalent Lung Dose and Systemic Exposure of Budesonide/Formoterol Combination via Easyhaler and Turbuhaler.

J Aerosol Med Pulm Drug Deliv. 2015-12

[10]
Evaluation of in vitro and in vivo flow rate dependency of budesonide/formoterol Easyhaler(®).

J Aerosol Med Pulm Drug Deliv. 2014-6-30

引用本文的文献

[1]
Insights from Real-World Evidence on the Use of Inhalers in Clinical Practice.

J Clin Med. 2025-2-12

[2]
Advancements in the Design and Development of Dry Powder Inhalers and Potential Implications for Generic Development.

Pharmaceutics. 2022-11-17

[3]
Narrative Review of the Role of Patient-Reported Outcomes and Inhaler Handling Errors in the Control of Asthma and COPD.

Curr Allergy Asthma Rep. 2022-11

[4]
Inhaled therapy for COVID-19: Considerations of drugs, formulations and devices.

Int J Pharm. 2022-8-25

[5]
Dry Powder Inhalers in the Digitalization Era: Current Status and Future Perspectives.

Pharmaceutics. 2021-9-12

[6]
Preference for Easyhaler Over Previous Dry Powder Inhalers in Asthma Patients: Results of the DPI PREFER Observational Study.

Patient Prefer Adherence. 2021-2-16

[7]
Traditional Chinese medicine combined with pulmonary drug delivery system and idiopathic pulmonary fibrosis: Rationale and therapeutic potential.

Biomed Pharmacother. 2021-1

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