可溶性 LDLR 的谜团：炎症会是关键吗？
The enigma of soluble LDLR: could inflammation be the key?
机构信息
Functional Endoproteolysis Laboratory, Clinical Research Institute of Montreal, 110 avenue des Pins Ouest, Montréal, Québec, H2W 1R7, Canada.
Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
出版信息
Lipids Health Dis. 2020 Feb 3;19(1):17. doi: 10.1186/s12944-020-1199-9.
Abstract
Soluble low-density lipoprotein receptor (sLDLR) is the circulating ectodomain of transmembrane LDLR. Its blood level strongly correlates with that of triglycerides (TG). This correlation has eluded satisfactory explanation. Hypertriglyceridemia and shedding of the ectodomain of many transmembrane receptors often accompany inflammatory states. The shedding mostly occurs through cleavage by a disintegrin-and-metalloproteinase-17 (ADAM-17), an enzyme activated by inflammation. It reduces the cellular uptake of TG-loaded lipoproteins, causing their accumulation in circulation; hence the correlation between plasma sLDLR and TG. Soluble LDLR could become a new surrogate marker of inflammation.
摘要
可溶性低密度脂蛋白受体（sLDLR）是跨膜 LDLR 的循环胞外结构域。其血液水平与甘油三酯（TG）强烈相关。这种相关性尚未得到满意的解释。高甘油三酯血症和许多跨膜受体的胞外结构域脱落通常伴随着炎症状态。这种脱落主要通过炎症激活的解整合素金属蛋白酶 17（ADAM-17）的切割来发生。它减少了载有 TG 的脂蛋白的细胞摄取，导致其在循环中积累；因此，血浆 sLDLR 与 TG 之间存在相关性。可溶性 LDLR 可能成为炎症的新替代标志物。
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