Research Center of Plasma Lipoprotein Immunology, College of Animal Medicine, Inner Mongolia Agricultural University, 306 Zhaowuda Road, Huhhot, 010018, China.
Microbiol Immunol. 2010 Apr;54(4):246-53. doi: 10.1111/j.1348-0421.2010.00203.x.
Plasma lipoproteins (VLDL, LDL, Lp[a] and HDL) function primarily in lipid transport among tissues and organs. However, cumulative evidence suggests that lipoproteins may also prevent bacterial, viral and parasitic infections and are therefore a component of innate immunity. Lipoproteins can also detoxify lipopolysaccharide and lipoteichoic acid. Infections can induce oxidation of LDL, and oxLDL in turn plays important anti-infective roles and protects against endotoxin-induced tissue damage. There is also evidence that apo(a) is protective against pathogens. Taken together, the evidence suggests that it might be valuable to introduce the concept that plasma lipoproteins belong in the realm of host immune response.
血浆脂蛋白（VLDL、LDL、Lp[a] 和 HDL）主要在组织和器官之间的脂质转运中发挥作用。然而，越来越多的证据表明，脂蛋白也可能预防细菌、病毒和寄生虫感染，因此是先天免疫的一个组成部分。脂蛋白还可以解毒脂多糖和脂磷壁酸。感染可诱导 LDL 氧化，而氧化 LDL 反过来又发挥重要的抗感染作用，并防止内毒素引起的组织损伤。也有证据表明载脂蛋白（a）对病原体具有保护作用。综上所述，有证据表明，引入血浆脂蛋白属于宿主免疫反应的范畴可能是有价值的。
