Nice Breast Institute, 57 bld de la Californie, 06000, Nice, France.
Stem Cell & Microenvironment Laboratory, Weill Cornell Medicine-Qatar, Doha, Qatar.
J Transl Med. 2020 Feb 3;18(1):52. doi: 10.1186/s12967-020-02244-9.
The concept of cancer as a cell-autonomous disease has been challenged by the wealth of knowledge gathered in the past decades on the importance of tumor microenvironment (TM) in cancer progression and metastasis. The significance of endothelial cells (ECs) in this scenario was initially attributed to their role in vasculogenesis and angiogenesis that is critical for tumor initiation and growth. Nevertheless, the identification of endothelial-derived angiocrine factors illustrated an alternative non-angiogenic function of ECs contributing to both physiological and pathological tissue development. Gene expression profiling studies have demonstrated distinctive expression patterns in tumor-associated endothelial cells that imply a bilateral crosstalk between tumor and its endothelium. Recently, some of the molecular determinants of this reciprocal interaction have been identified which are considered as potential targets for developing novel anti-angiocrine therapeutic strategies.
癌症作为一种细胞自主性疾病的概念，受到过去几十年在肿瘤微环境（TM）在癌症进展和转移中的重要性方面积累的大量知识的挑战。在这种情况下，内皮细胞（ECs）的重要性最初归因于它们在血管发生和血管生成中的作用，这对于肿瘤的发生和生长至关重要。然而，内皮衍生的血管生成因子的鉴定说明了 ECs 的另一种非血管生成功能，有助于生理和病理组织的发育。基因表达谱研究表明，肿瘤相关内皮细胞中存在独特的表达模式，这暗示了肿瘤与其内皮细胞之间的双向串扰。最近，已经确定了这种相互作用的一些分子决定因素，这些因素被认为是开发新型抗血管生成治疗策略的潜在靶点。
