Wu Hua-Tao, Zhong Hui-Ting, Li Guan-Wu, Shen Jia-Xin, Ye Qian-Qian, Zhang Man-Li, Liu Jing
Department of General Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, China.
Changjiang Scholar's Laboratory/Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Breast Cancer, Shantou University Medical College, Shantou, 515041, China.
J Transl Med. 2020 Feb 3;18(1):51. doi: 10.1186/s12967-020-02240-z.
Zinc finger E-box binding homeobox 1 (ZEB1, also termed TCF8 and δEF1) is a crucial member of the zinc finger-homeodomain transcription factor family, originally identified as a binding protein of the lens-specific δ1-crystalline enhancer and is a pivotal transcription factor in the epithelial-mesenchymal transition (EMT) process. ZEB1 also plays a vital role in embryonic development and cancer progression, including breast cancer progression. Increasing evidence suggests that ZEB1 stimulates tumor cells with mesenchymal traits and promotes multidrug resistance, proliferation, and metastasis, indicating the importance of ZEB1-induced EMT in cancer development. ZEB1 expression is regulated by multiple signaling pathways and components, including TGF-β, β-catenin, miRNA and other factors. Here, we summarize the recent discoveries of the functions and mechanisms of ZEB1 to understand the role of ZEB1 in EMT regulation in breast cancer.
锌指 E 盒结合同源框 1（ZEB1，也称为 TCF8 和δEF1）是锌指 - 同源结构域转录因子家族的关键成员，最初被鉴定为晶状体特异性δ1 - 晶体蛋白增强子的结合蛋白，并且是上皮 - 间质转化（EMT）过程中的关键转录因子。ZEB1 在胚胎发育和癌症进展（包括乳腺癌进展）中也起着至关重要的作用。越来越多的证据表明，ZEB1 刺激具有间质特征的肿瘤细胞并促进多药耐药性、增殖和转移，这表明 ZEB1 诱导的 EMT 在癌症发展中的重要性。ZEB1 的表达受多种信号通路和成分调节，包括转化生长因子 -β（TGF -β）、β - 连环蛋白、微小 RNA（miRNA）和其他因素。在此，我们总结了 ZEB1 功能和机制的最新发现，以了解 ZEB1 在乳腺癌 EMT 调节中的作用。
