伤害感受器-肥大细胞感觉簇作为皮肤稳态的调节剂。
Nociceptor-Mast Cell Sensory Clusters as Regulators of Skin Homeostasis.
机构信息
The Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.
Unité de Différenciation Epithéliale et Autoimmunité Rhumatoïde (UDEAR), UMR 1056, INSERM, Université de Toulouse, 31059 Toulouse, France.
出版信息
Trends Neurosci. 2020 Mar;43(3):130-132. doi: 10.1016/j.tins.2020.01.001. Epub 2020 Jan 31.
Recent studies revealed the existence of unique functional links between mast cells and nociceptors in the skin. Here, we propose that mast cells and nociceptors form a single regulatory unit in both physiology and disease. In this model, MrgprB2/X2 signaling is a primary mechanism by which mast cells functionally interact with nociceptors to form specialized neuroimmune clusters that regulate pain, inflammation, and itch.
最近的研究揭示了皮肤中的肥大细胞和伤害感受器之间存在独特的功能联系。在这里，我们提出肥大细胞和伤害感受器在生理和疾病中形成一个单一的调节单元。在这个模型中，MrgprB2/X2 信号是肥大细胞与伤害感受器进行功能相互作用，形成专门的神经免疫簇以调节疼痛、炎症和瘙痒的主要机制。
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