Postgraduate Programme in Health and Behavior - Catholic University of Pelotas (UCPel), Gonçalves Chaves, 377 - 411 C - 96015-560, Pelotas, RS, Brazil.
Postgraduate Programme in Health and Behavior - Catholic University of Pelotas (UCPel), Gonçalves Chaves, 377 - 411 C - 96015-560, Pelotas, RS, Brazil.
Vaccine. 2020 Feb 24;38(9):2216-2220. doi: 10.1016/j.vaccine.2019.12.044. Epub 2020 Jan 31.
The discussion on the safety of thimerosal-containing vaccines (TCVs) and their impact on child development it́s very relevant.
This is a cohort study with mother-child dyads who received prenatal care in the Unified Health System. The domains of motor, cognitive and language development were evaluated in children between 24 and 36 months of age. Data on vaccination were obtained through the child's immunization record. A linear regression analysis was carried out considering possible confounders.
In bivariate analyses, motor and language development were associated with TCVs (p < 0.05). However, in the multivariate analysis, this association was not maintained (p > 0.05). These results indicate that the use of TCVs is not associated with child development. The importance of this study is summarized in transmitting relevant information regarding public health, based on reliable data.
关于含硫柳汞疫苗（TCVs）的安全性及其对儿童发育影响的讨论非常重要。
这是一项队列研究，纳入了在统一卫生系统中接受产前保健的母婴对子。在儿童 24 至 36 个月时，评估其运动、认知和语言发育领域。通过儿童免疫记录获取疫苗接种数据。考虑到可能的混杂因素，进行了线性回归分析。
在单变量分析中，运动和语言发育与 TCVs 相关（p<0.05）。然而，在多变量分析中，这种关联并不成立（p>0.05）。这些结果表明，TCVs 的使用与儿童发育无关。本研究的重要性在于基于可靠数据传递有关公共卫生的相关信息。
