常见 eNOS 基因多态性与冠心病易感性的关系：来自 155 项已发表关联研究的荟萃分析证据。
Relationship between common eNOS gene polymorphisms and predisposition to coronary artery disease: Evidence from a meta-analysis of 155 published association studies.
机构信息
Department of Geriatric, Affiliated Hospital of Shaoxing University, Shaoxing 312000, China.
Department of Geriatric, Affiliated Hospital of Shaoxing University, Shaoxing 312000, China..
出版信息
Genomics. 2020 May;112(3):2452-2458. doi: 10.1016/j.ygeno.2020.01.019. Epub 2020 Jan 31.
BACKGROUND
Relationship between endothelial nitric oxide synthase (eNOS) polymorphisms and predisposition to coronary artery disease (CAD) are still controversial and ambiguous. So we performed this meta-analysis to more precisely estimate relationship between eNOS polymorphisms and CAD by pooling the results of already published studies.
METHODS
We searched Pubmed, Embase, Web of Science and CNKI for eligible studies. We used Review Manager to pool the results of eligible studies.
RESULTS
One hundred and fifty-five studies were included in this meta-analysis. We found that eNOS rs1799983, rs2070744 and rs869109213 polymorphisms were all significantly associated with CAD in the general population. We also detected similar significant results for eNOS rs1799983, rs2070744 and rs869109213 polymorphisms in both Caucasians and Asians in further subgroup analyses.
CONCLUSIONS
This meta-analysis demonstrated that eNOS rs1799983, rs2070744 and rs869109213 polymorphisms might influence predisposition to CAD in both Caucasians and Asians.
背景
内皮型一氧化氮合酶（eNOS）多态性与冠心病（CAD）易感性之间的关系仍存在争议和不明确。因此，我们进行了这项荟萃分析，通过合并已发表研究的结果，更准确地估计 eNOS 多态性与 CAD 之间的关系。
方法
我们在 Pubmed、Embase、Web of Science 和中国知网（CNKI）中搜索了符合条件的研究。我们使用 Review Manager 合并符合条件的研究结果。
结果
这项荟萃分析共纳入了 155 项研究。我们发现，eNOS rs1799983、rs2070744 和 rs869109213 多态性在一般人群中均与 CAD 显著相关。我们在进一步的亚组分析中也发现，eNOS rs1799983、rs2070744 和 rs869109213 多态性在白人和亚洲人中也存在类似的显著结果。
结论
这项荟萃分析表明，eNOS rs1799983、rs2070744 和 rs869109213 多态性可能影响白人和亚洲人中 CAD 的易感性。
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