Department of Gastroenterology, Shangqiu First People's Hospital, Shangqiu, Henan, China.
Department of Gastroenterology, Shangqiu First People's Hospital, Shangqiu, Henan, China.
Nitric Oxide. 2019 Mar 1;84:1-6. doi: 10.1016/j.niox.2018.12.006. Epub 2018 Dec 22.
Whether endothelial nitric oxide synthase (eNOS) polymorphisms are implicated in cancer development remains controversial. Therefore, we performed this study to obtain a more conclusive result on associations between eNOS polymorphisms and cancer.
Literature retrieve was conducted in PubMed, Medline and Embase. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.
Forty-one studies were enrolled for analyses. Pooled overall analyses showed that rs1799983 (dominant model: p = 0.01; recessive model: p = 0.007; allele model: p = 0.005), rs2070744 (recessive model: p = 0.004) and rs869109213 (recessive model: p < 0.0001; allele model: p = 0.02) polymorphisms were all significantly associated with individual susceptibility to cancer. Further subgroup analyses revealed that rs2070744 and rs869109213 polymorphisms were only significantly associated with individual susceptibility to cancer in Caucasians, whereas the rs1799983 polymorphism was significantly associated with individual susceptibility to cancer in both Caucasians and Asians.
Our findings indicated that rs1799983, rs2070744 and rs869109213 polymorphisms may serve as genetic biomarkers of cancer in certain ethnicities.
内皮型一氧化氮合酶（eNOS）多态性是否与癌症发展有关仍存在争议。因此，我们进行了这项研究，以获得关于 eNOS 多态性与癌症之间关联的更具结论性的结果。
在 PubMed、Medline 和 Embase 中进行文献检索。计算了比值比（ORs）和 95%置信区间（CIs）。
有 41 项研究纳入分析。汇总的总体分析显示，rs1799983（显性模型：p=0.01；隐性模型：p=0.007；等位基因模型：p=0.005）、rs2070744（隐性模型：p=0.004）和 rs869109213（隐性模型：p<0.0001；等位基因模型：p=0.02）多态性均与个体患癌症的易感性显著相关。进一步的亚组分析显示，rs2070744 和 rs869109213 多态性仅与高加索人群个体患癌症的易感性显著相关，而 rs1799983 多态性与高加索人群和亚洲人群个体患癌症的易感性均显著相关。
我们的研究结果表明，rs1799983、rs2070744 和 rs869109213 多态性可能是某些种族癌症的遗传生物标志物。
