长非编码 RNA 与白血病的关联：系统评价。
Association of long non-coding RNA and leukemia: A systematic review.
机构信息
Universidade Feevale, Novo Hamburgo, Rio Grande do Sul, Brazil.
Universidade Feevale, Novo Hamburgo, Rio Grande do Sul, Brazil.
出版信息
Gene. 2020 Apr 20;735:144405. doi: 10.1016/j.gene.2020.144405. Epub 2020 Jan 31.
INTRODUCTION
Long non-coding RNAs (lncRNAs) are RNA molecules that structurally resemble mRNA but do not encode proteins. Studies have been associated this class of non-coding RNA with the development of several disease, among them the different types of leukemia. However, the results are contradictory. Thus, we performed a systematic review of the literature available in order to better understand the involvement of lncRNAs in the development of leukemia.
MATERIALS AND METHODS
Pubmed and Embase databases were used to identify all studies that evaluated the expression of one or more lncRNA between human samples (peripheral blood, bone marrow) with leukemia (cases) and without leukemia (controls).
RESULTS
A total of 3675 articles were found in the databases, and after exclusion of articles that did not meet the eligibility criteria, 86 articles were included in this systematic review. In the 86 included studies, 3927 lncRNAs were differentially expressed between cases and controls. Among these, 110 lncRNAs were reported as being altered in samples from at least 2 studies and only 16 of them in ≥3 studies, which were selected for further evaluation. Of these, 12 lncRNAs were consistently dysregulated between cases and controls (CCAT1, CCDC26, CRNDE, HOTAIR, KCNQ5IT1, LINC00265, MALAT1, PVT1, SNHG5, TUG1: increased in cases, MEG3 and NEAT1: decreased in cases) in human samples of patients with some type of leukemia.
CONCLUSION
Our data demonstrate that 12 lncRNAs are dysregulated in leukemia.
简介
长链非编码 RNA（lncRNAs）是一种结构上类似于 mRNA 但不编码蛋白质的 RNA 分子。研究已经将这类非编码 RNA 与多种疾病的发生联系起来，其中包括不同类型的白血病。然而，结果却存在矛盾。因此，我们进行了系统的文献回顾，以便更好地了解 lncRNAs 参与白血病的发生机制。
材料和方法
使用 Pubmed 和 Embase 数据库，检索评估人类样本（外周血、骨髓）中 lncRNA 表达的所有研究，这些样本来自白血病（病例）和非白血病（对照）患者。
结果
在数据库中总共发现了 3675 篇文章，排除不符合入选标准的文章后，共有 86 篇文章纳入本系统评价。在纳入的 86 项研究中，3927 个 lncRNAs 在病例和对照之间存在差异表达。其中，有 110 个 lncRNAs 在至少 2 项研究的样本中被报道为改变，而在≥3 项研究中被报道为改变的仅有 16 个，这些 lncRNAs被进一步评估。其中，在病例和对照之间存在一致性失调的有 12 个 lncRNAs（CCAT1、CCDC26、CRNDE、HOTAIR、KCNQ5IT1、LINC00265、MALAT1、PVT1、SNHG5、TUG1：在病例中上调，MEG3 和 NEAT1：在病例中下调），这些 lncRNAs存在于某些类型的白血病患者的人类样本中。
结论
我们的数据表明，12 个 lncRNAs 在白血病中失调。
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