Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363 Lodz, Poland.
Department of Chemistry, School of Life Sciences, University of Sussex, Brighton BN1 9QJ, UK.
Bioorg Chem. 2020 Mar;96:103617. doi: 10.1016/j.bioorg.2020.103617. Epub 2020 Jan 25.
Anthracyclines (Anth) are widely used in the treatment of various types of cancer. Unfortunately, they exhibit serious adverse effects, such as hematopoietic depression and cardiotoxicity, leading to heart failure. In this review, we focus on recently developed conjugates of anthracyclines with a range of nanocarriers, such as polymers, peptides, DNA or inorganic systems. Manipulation of the composition, size and shape of chemical entities at the nanometer scale makes possible the design and development of a range of prodrugs. In this review we concentrate on synthetic chemistry in the long process leading to the introduction of novel therapeutic products.
蒽环类药物（Anth）广泛用于治疗各种类型的癌症。不幸的是，它们表现出严重的不良反应，如造血抑制和心脏毒性，导致心力衰竭。在这篇综述中，我们专注于最近开发的蒽环类药物与一系列纳米载体的缀合物，如聚合物、肽、DNA 或无机系统。在纳米尺度上对化学实体的组成、大小和形状进行操控，使得设计和开发一系列前药成为可能。在这篇综述中，我们集中讨论了导致新型治疗产品问世的漫长合成化学过程。
