新生儿视觉诱发电位延迟与双胞胎的不对称生长模式有关。

Delayed neonatal visual evoked potentials are associated to asymmetric growth pattern in twins.

机构信息

University Hospital "P. Giaccone", Department of Sciences for Health Promotion, Maternal Infant Care, Internal Medicine and Medical Specialties "G. D'Alessandro", Neonatal Intensive Care Unit, Via A. Giordano 3, 90127 Palermo, Italy.

University Hospital Arcispedale Sant'Anna, Department of Medical Sciences, Pediatric Section, Via Aldo Moro 8, 44124 Cona, Ferrara, Italy.

出版信息

Clin Neurophysiol. 2020 Mar;131(3):744-749. doi: 10.1016/j.clinph.2019.12.407. Epub 2020 Jan 20.

DOI:10.1016/j.clinph.2019.12.407

PMID:32014681

Abstract

OBJECTIVES

To study the association between intrauterine growth and visual pathways maturation by neonatal visual evoked potentials (VEPs) in twins, in view of a possible prognostic role.

METHODS

Seventy-four twin neonates from 37 pregnancies were selected based on gestational age of more than 30 weeks and uneventful perinatal clinical course. Flash VEPs were recorded at the same postmenstrual age in each twin pair. The association between P2 latency and anthropometric variables at birth was analyzed by comparison within each twin pair and regarding each variable as ordered difference between the two twins.

RESULTS

Analysis of differences within each twin pair highlighted that inter-twin difference in P2 latency was significantly related to difference in ponderal index (PI) (p = 0.048). Expressing the difference in latency as a categorical binary variable, the correlation was significant for both difference in PI, (median difference = -0.36, 95% CI -0.54 to -0.14, p = 0.001) and difference in body mass index (BMI), (median difference = -1.06, 95% CI -1.74 to -0.29, p = 0.006).

CONCLUSIONS

Lower values of PI and BMI differences are associated to delayed VEP latency in twin pairs.

SIGNIFICANCE

VEP latency suggests reduced myelination of visual pathways when difference in growth pattern occurs in twins.

摘要

目的

通过对双胞胎新生儿视觉诱发电位（VEPs）的研究，探讨宫内生长与视觉通路成熟之间的关系，以期探讨其可能的预后作用。

方法

根据妊娠 30 周以上且围产期临床过程无异常的标准，选择 37 例妊娠的 74 对双胞胎新生儿。在每个双胞胎中，以相同的胎龄记录闪光 VEPs。通过比较每个双胞胎内的差异以及将每个变量视为双胞胎之间的有序差异，分析 P2 潜伏期与出生时人体测量学变量之间的关系。

结果

对每个双胞胎内的差异进行分析，结果表明 P2 潜伏期的双胞胎间差异与体重指数（PI）的差异显著相关（p=0.048）。将潜伏期差异表示为分类二变量时，PI 差异（中位数差异=-0.36，95%置信区间-0.54 至-0.14，p=0.001）和体重指数（BMI）差异（中位数差异=-1.06，95%置信区间-1.74 至-0.29，p=0.006）的相关性均具有统计学意义。