• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

间日疟原虫红内期抗原 RBP2-P1 与网织红细胞结合，是天然免疫的靶标。

The Blood Stage Antigen RBP2-P1 of Plasmodium vivax Binds Reticulocytes and Is a Target of Naturally Acquired Immunity.

机构信息

Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

出版信息

Infect Immun. 2020 Mar 23;88(4). doi: 10.1128/IAI.00616-19.

DOI:10.1128/IAI.00616-19
PMID:32014895
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7093139/
Abstract

The interactions between parasites and human erythrocytes are prime targets of blood stage malaria vaccine development. The reticulocyte binding protein 2-P1 (RBP2-P1) of , a member of the reticulocyte binding protein family, has recently been shown to be highly antigenic in several settings endemic for malaria. Yet, its functional characteristics and the relevance of its antibody response in human malaria have not been examined. In this study, the potential function of RBP2-P1 as an invasion ligand of was evaluated. The protein was found to be expressed in schizonts, be localized at the apical end of the merozoite, and preferentially bind reticulocytes over normocytes. Human antibodies to this protein also exhibit erythrocyte binding inhibition at physiologically relevant concentrations. Furthermore, RBP2-P1 antibodies are associated with lower parasitemia and tend to be higher in asymptomatic carriers than in patients. This study provides evidence supporting a role of RBP2-P1 as an invasion ligand and its consideration as a vaccine target.

摘要

寄生虫与人类红细胞的相互作用是血阶段疟疾疫苗开发的主要目标。 裂殖体结合蛋白 2-P1（RBP2-P1）是裂殖体结合蛋白家族的成员，最近在疟疾流行地区的几个地方被证明具有高度抗原性。 然而，其抗体反应的功能特征及其在人类疟疾中的相关性尚未得到检验。 在这项研究中，评估了 RBP2-P1 作为 入侵配体的潜在功能。 发现该蛋白在裂殖体中表达，定位于裂殖体的顶端，并且优先结合网织红细胞而不是正常红细胞。 针对该蛋白的人抗体在生理相关浓度下也表现出红细胞结合抑制作用。 此外，RBP2-P1 抗体与较低的寄生虫血症相关，并且在无症状携带者中比在患者中倾向于更高。 这项研究提供了支持 RBP2-P1 作为入侵配体的作用及其作为疫苗靶标的证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/855d/7093139/6e3d1e69b831/IAI.00616-19-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/855d/7093139/dadc61a6c8ca/IAI.00616-19-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/855d/7093139/2b6932e14cb1/IAI.00616-19-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/855d/7093139/23bb2d83a1cc/IAI.00616-19-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/855d/7093139/8844d74d7b27/IAI.00616-19-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/855d/7093139/9492eb8f4d29/IAI.00616-19-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/855d/7093139/bef68cb427dc/IAI.00616-19-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/855d/7093139/6e3d1e69b831/IAI.00616-19-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/855d/7093139/dadc61a6c8ca/IAI.00616-19-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/855d/7093139/2b6932e14cb1/IAI.00616-19-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/855d/7093139/23bb2d83a1cc/IAI.00616-19-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/855d/7093139/8844d74d7b27/IAI.00616-19-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/855d/7093139/9492eb8f4d29/IAI.00616-19-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/855d/7093139/bef68cb427dc/IAI.00616-19-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/855d/7093139/6e3d1e69b831/IAI.00616-19-f0007.jpg

相似文献

1
The Blood Stage Antigen RBP2-P1 of Plasmodium vivax Binds Reticulocytes and Is a Target of Naturally Acquired Immunity.间日疟原虫红内期抗原 RBP2-P1 与网织红细胞结合，是天然免疫的靶标。
Infect Immun. 2020 Mar 23;88(4). doi: 10.1128/IAI.00616-19.
2
Identification and Immunological Characterization of the Ligand Domain of Plasmodium vivax Reticulocyte Binding Protein 1a.鉴定和免疫鉴定恶性疟原虫环状体结合蛋白 1a 的配体结构域。
J Infect Dis. 2018 Aug 24;218(7):1110-1118. doi: 10.1093/infdis/jiy273.
3
Targeting a Reticulocyte Binding Protein and Duffy Binding Protein to Inhibit Reticulocyte Invasion by Plasmodium vivax.靶向网织红细胞结合蛋白和趋化因子受体 Duffy 抑制间日疟原虫对网织红细胞的入侵。
Sci Rep. 2018 Jul 12;8(1):10511. doi: 10.1038/s41598-018-28757-4.
4
Naturally Acquired Human Antibodies Against Reticulocyte-Binding Domains of Plasmodium vivax Proteins, PvRBP2c and PvRBP1a, Exhibit Binding-Inhibitory Activity.针对间日疟原虫蛋白PvRBP2c和PvRBP1a的网织红细胞结合结构域的天然获得性人类抗体具有结合抑制活性。
J Infect Dis. 2017 May 15;215(10):1558-1568. doi: 10.1093/infdis/jix170.
5
Functional and Immunologic Mapping of Domains of the Reticulocyte-Binding Protein Plasmodium vivax PvRBP2a.红细胞结合蛋白 2a 结构域的功能和免疫定位分析。
J Infect Dis. 2024 Sep 23;230(3):e737-e742. doi: 10.1093/infdis/jiae111.
6
Antibody responses within two leading Plasmodium vivax vaccine candidate antigens in three geographically diverse malaria-endemic regions of India.在印度三个地理上不同的疟疾流行地区，两种主要的间日疟原虫候选疫苗抗原的抗体反应。
Malar J. 2019 Dec 16;18(1):425. doi: 10.1186/s12936-019-3066-6.
7
Naturally Acquired Binding-Inhibitory Antibodies to Plasmodium vivax Duffy Binding Protein and Clinical Immunity to Malaria in Rural Amazonians.对间日疟原虫达菲结合蛋白的天然获得性结合抑制抗体与亚马逊农村地区人群对疟疾的临床免疫
J Infect Dis. 2016 Nov 15;214(10):1539-1546. doi: 10.1093/infdis/jiw407. Epub 2016 Aug 30.
8
Plasmodium vivax Reticulocyte Binding Proteins for invasion into reticulocytes.恶性疟原虫 （Plasmodium vivax） 红细胞内期入侵相关的结合蛋白。
Cell Microbiol. 2020 Jan;22(1):e13110. doi: 10.1111/cmi.13110. Epub 2019 Sep 8.
9
Immunogenicity of the Plasmodium vivax merozoite surface protein 1 paralog in the induction of naturally acquired antibody and memory B cell responses.间日疟原虫裂殖子表面蛋白1旁系同源物在诱导自然获得性抗体和记忆B细胞反应中的免疫原性。
Malar J. 2017 Aug 30;16(1):354. doi: 10.1186/s12936-017-2000-z.
10
Structural basis for inhibition of Plasmodium vivax invasion by a broadly neutralizing vaccine-induced human antibody.结构基础为广泛中和疫苗诱导的人抗体抑制间日疟原虫入侵。
Nat Microbiol. 2019 Sep;4(9):1497-1507. doi: 10.1038/s41564-019-0462-1. Epub 2019 May 27.

引用本文的文献

1
Profiling the antibody response of humans protected by immunization with Plasmodium vivax radiation-attenuated sporozoites.分析经疟原虫 vivax 辐射减毒子孢子免疫保护的人类的抗体反应。
Sci Rep. 2024 Feb 2;14(1):2790. doi: 10.1038/s41598-024-53175-0.
2
vaccine: What is the best way to go?疫苗：哪种途径最好？
Front Immunol. 2023 Jan 16;13:910236. doi: 10.3389/fimmu.2022.910236. eCollection 2022.
3
Systems biology of malaria explored with nonhuman primates.用非人类灵长类动物探索疟疾的系统生物学。

本文引用的文献

1
Highly heterogeneous residual malaria risk in western Thailand.泰国西部高度异质的疟疾残留风险。
Int J Parasitol. 2019 May;49(6):455-462. doi: 10.1016/j.ijpara.2019.01.004. Epub 2019 Apr 4.
2
Targets of complement-fixing antibodies in protective immunity against malaria in children.儿童疟疾保护性免疫中补体固定抗体的靶标。
Nat Commun. 2019 Feb 5;10(1):610. doi: 10.1038/s41467-019-08528-z.
3
Anti-MSP11 IgG inhibits Plasmodium falciparum merozoite invasion into erythrocytes in vitro.抗疟原虫裂殖子表面蛋白11 IgG抗体在体外可抑制恶性疟原虫裂殖子侵入红细胞。
Malar J. 2022 Jun 7;21(1):177. doi: 10.1186/s12936-022-04199-2.
4
The role of naturally acquired antimalarial antibodies in subclinical Plasmodium spp. infection.天然获得的抗疟抗体在亚临床疟原虫感染中的作用。
J Leukoc Biol. 2022 May;111(5):1097-1105. doi: 10.1002/JLB.5MR1021-537R. Epub 2022 Jan 20.
5
Plasmodium vivax binds host CD98hc (SLC3A2) to enter immature red blood cells.恶性疟原虫通过结合宿主 CD98hc（SLC3A2）入侵未成熟的红细胞。
Nat Microbiol. 2021 Aug;6(8):991-999. doi: 10.1038/s41564-021-00939-3. Epub 2021 Jul 22.
6
Naturally induced humoral response against Plasmodium vivax reticulocyte binding protein 2P1.天然诱导的针对间日疟原虫环状体结合蛋白 2P1 的体液免疫应答。
Malar J. 2021 Jun 3;20(1):246. doi: 10.1186/s12936-021-03784-1.
7
Alternative Invasion Mechanisms and Host Immune Response to Malaria: Trends and Future Directions.疟疾的替代入侵机制与宿主免疫反应：趋势与未来方向
Microorganisms. 2020 Dec 23;9(1):15. doi: 10.3390/microorganisms9010015.
Parasitol Int. 2019 Apr;69:25-29. doi: 10.1016/j.parint.2018.10.012. Epub 2018 Oct 30.
4
Evolutionary history of human revealed by genome-wide analyses of related ape parasites.人类的进化历史通过对相关猿类寄生虫的全基因组分析揭示出来。
Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):E8450-E8459. doi: 10.1073/pnas.1810053115. Epub 2018 Aug 20.
5
Targeting a Reticulocyte Binding Protein and Duffy Binding Protein to Inhibit Reticulocyte Invasion by Plasmodium vivax.靶向网织红细胞结合蛋白和趋化因子受体 Duffy 抑制间日疟原虫对网织红细胞的入侵。
Sci Rep. 2018 Jul 12;8(1):10511. doi: 10.1038/s41598-018-28757-4.
6
Transferrin receptor 1 is a reticulocyte-specific receptor for .转铁蛋白受体1是一种针对……的网织红细胞特异性受体。
Science. 2018 Jan 5;359(6371):48-55. doi: 10.1126/science.aan1078.
7
Naturally acquired antibody responses to more than 300 Plasmodium vivax proteins in three geographic regions.三个地理区域中对300多种间日疟原虫蛋白的自然获得性抗体反应。
PLoS Negl Trop Dis. 2017 Sep 11;11(9):e0005888. doi: 10.1371/journal.pntd.0005888. eCollection 2017 Sep.
8
Naturally Acquired Human Antibodies Against Reticulocyte-Binding Domains of Plasmodium vivax Proteins, PvRBP2c and PvRBP1a, Exhibit Binding-Inhibitory Activity.针对间日疟原虫蛋白PvRBP2c和PvRBP1a的网织红细胞结合结构域的天然获得性人类抗体具有结合抑制活性。
J Infect Dis. 2017 May 15;215(10):1558-1568. doi: 10.1093/infdis/jix170.
9
Plasmodium vivax Reticulocyte Binding Proteins Are Key Targets of Naturally Acquired Immunity in Young Papua New Guinean Children.间日疟原虫网织红细胞结合蛋白是巴布亚新几内亚幼儿自然获得性免疫的关键靶点。
PLoS Negl Trop Dis. 2016 Sep 27;10(9):e0005014. doi: 10.1371/journal.pntd.0005014. eCollection 2016 Sep.
10
A Novel Erythrocyte Binding Protein of Plasmodium vivax Suggests an Alternate Invasion Pathway into Duffy-Positive Reticulocytes.间日疟原虫一种新型红细胞结合蛋白提示进入达菲阳性网织红细胞的另一种入侵途径。
mBio. 2016 Aug 23;7(4):e01261-16. doi: 10.1128/mBio.01261-16.