启动子多态性与胃癌的关联。
The Association of Promoter Polymorphisms With Gastric Cancer.
机构信息
Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
Taichung Armed Forces General Hospital, Taichung, Taiwan, R.O.C.
出版信息
Anticancer Res. 2020 Feb;40(2):695-702. doi: 10.21873/anticanres.13999.
BACKGROUND/AIM: Few studies have examined the genetic role of matrix metalloproteinases (MMPs) to early detection or prediction in gastric cancer development. In this study, the contribution of MMP7 promoter (A-181G and C-153T) polymorphic genotypes to gastric cancer risk in Taiwanese was investigated for the first time.
MATERIALS AND METHODS
A total of 121 cases and 363 controls were enrolled and their MMP7 genotypes at A-181G and C-153T were examined by polymerase chain reaction-restriction fragment length polymorphism methodology using genomic DNA from serum.
RESULTS
The GG genotype at MMP7 A-181G was found to represent a risk factor for gastric cancer, especially among smokers. No individual with variant genotype carrier at MMP7 C-153T was found among this Taiwanese population.
CONCLUSION
The G allele of MMP7 A-181G may serve as an early predictor for gastric cancer risk in Taiwanese; other gastric cancer markers are still urgently needed.
背景/目的：很少有研究探讨基质金属蛋白酶（MMPs）在胃癌发生中的遗传作用，以进行早期检测或预测。本研究首次探讨了 MMP7 启动子（A-181G 和 C-153T）多态基因型对台湾地区胃癌风险的贡献。
材料和方法
共纳入 121 例病例和 363 例对照，采用聚合酶链反应-限制性片段长度多态性方法，使用血清中的基因组 DNA 检测 MMP7 A-181G 和 C-153T 的基因型。
结果
MMP7 A-181G 的 GG 基因型被发现是胃癌的危险因素，尤其是在吸烟者中。在台湾人群中未发现 MMP7 C-153T 变异基因型携带者。
结论
MMP7 A-181G 的 G 等位基因可能是台湾地区胃癌风险的早期预测指标；仍迫切需要其他胃癌标志物。
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