基因型与翼状胬肉的相关性。
The Association of Genotype With Pterygium.
机构信息
Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
Department of Ophthalmology, Changhua Christian Hospital, Changhua, Taiwan, R.O.C.
出版信息
In Vivo. 2020 Jan-Feb;34(1):51-56. doi: 10.21873/invivo.11744.
BACKGROUND/AIM: In literature, few studies have examined the diagnostic or prognostic potential of matrix metalloproteinases (MMP) in pterygium, whose formation and progression are closely related to imbalance in the extracellular microenvironment. In this study, we investigated the contribution of MMP7 promoter (A-181G and C-153T) polymorphic genotypes to pterygium risk.
MATERIALS AND METHODS
A total of 134 cases and 268 controls were collected and their MMP7 genotypes at A-181G and C-153T were examined by polymerase chain reaction-restriction fragment length polymorphism methodology.
RESULTS
The AA, AG and GG genotypes at MMP7 promoter A-181G were non-significantly differentially distributed between the two groups at 85.8, 11.2 and 3.0%, respectively, in pterygium cases and 88.4, 9.7 and 1.9% in controls, respectively (p for trend=0.6822). There was no polymorphic genotype for MMP7 C-153T among our Taiwanese cohort.
CONCLUSION
A-181G and C-153T genotypes at MMP7 do not have a direct role in determining Taiwanese susceptibility to pterygium.
背景/目的：在文献中，很少有研究探讨基质金属蛋白酶（MMP）在翼状胬肉中的诊断或预后潜力，其形成和进展与细胞外微环境的失衡密切相关。在这项研究中，我们研究了 MMP7 启动子（A-181G 和 C-153T）多态基因型对翼状胬肉风险的贡献。
材料和方法
共收集了 134 例病例和 268 例对照，并采用聚合酶链反应-限制性片段长度多态性方法检测 MMP7 基因型在 A-181G 和 C-153T 处的多态性。
结果
在翼状胬肉病例中，MMP7 启动子 A-181G 处的 AA、AG 和 GG 基因型分别为 85.8%、11.2%和 3.0%，而对照组分别为 88.4%、9.7%和 1.9%（趋势检验的 p 值=0.6822）。在我们的台湾队列中，MMP7 C-153T 没有多态基因型。
结论
MMP7 的 A-181G 和 C-153T 基因型不能直接决定台湾人对翼状胬肉的易感性。
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