Gastrointestinal Medical Oncology Division, National Cancer Center Hospital, Tokyo, Japan.
Gastrointestinal Medical Oncology Division, National Cancer Center Hospital, Tokyo, Japan
Anticancer Res. 2020 Feb;40(2):1071-1077. doi: 10.21873/anticanres.14045.
BACKGROUND/AIM: Severe benign cicatricial stricture (SBCS) is a major complication after definitive chemoradiation therapy (dCRT) for esophageal squamous cell carcinoma (ESCC). This study was conducted to investigate risk factors of SBCS in patients with localized ESCC.
This study included 197 patients with clinical stage (cSt) II/III ESCC with T3 primary tumor, treated with dCRT between 2000 and 2011. SBCS was defined as the inability to pass a 9-mm diameter endoscope or the presence of symptoms requiring treatment.
Complete response was obtained in 87 patients (44%). Multivariate analysis revealed that hypoalbuminemia (hazard ratio=5.65; 95% confidence interval=1.50-21.28; p=0.010) and the inability to pass an endoscope (hazard ratio=5.90; 95% confidence interval=1.52-22.85; p=0.010) were risk factors of SBCS.
The inability to pass an endoscope and hypoalbuminemia were identified as risk factors of SBCS in patients with cSt II/III ESCC with T3 primary tumor.
背景/目的：严重良性瘢痕性狭窄（SBCS）是食管鳞状细胞癌（ESCC）根治性放化疗（dCRT）后主要的并发症。本研究旨在探讨局部 ESCC 患者发生 SBCS 的危险因素。
本研究纳入了 197 例临床分期（cSt）为 II/III 期且 T3 期肿瘤的 ESCC 患者，他们接受了 2000 年至 2011 年之间的 dCRT 治疗。SBCS 定义为无法通过 9mm 直径的内镜或存在需要治疗的症状。
87 例患者（44%）获得完全缓解。多因素分析显示，低白蛋白血症（危险比=5.65；95%置信区间=1.50-21.28；p=0.010）和无法通过内镜（危险比=5.90；95%置信区间=1.52-22.85；p=0.010）是 SBCS 的危险因素。
无法通过内镜和低白蛋白血症是 cSt II/III 期 T3 期肿瘤患者发生 SBCS 的危险因素。
