Department of Surgery, Yokohama City University, Yokohama, Japan
Department of Surgery, Yokohama City University, Yokohama, Japan.
Anticancer Res. 2020 Feb;40(2):1087-1093. doi: 10.21873/anticanres.14047.
The short- and long-term outcomes of esophagectomy for esophageal cancer were fully evaluated in patients older than 75 years of age.
The present study selected patients who received esophagectomy for esophageal cancer. Patients were divided into non-elderly patients [age <75 years (non-elderly group)] and elderly patients [age ≥75 years (elderly group)]. The postoperative surgical morbidity, postoperative 30-days mortality, recurrence-free survival (RFS), and overall survival (OS) rates were evaluated between the non-elderly group and elderly group.
One hundred twenty-two patients were evaluated in this study. Ninety-eight patients and 24 patients were classified into the non-elderly group and elderly group, respectively. The postoperative surgical complication rates in the non-elderly and elderly groups were 71.4% and 75.0%. There was not a statistically significant difference between the two groups (p=0.710). Mortality was observed in 1 patient in the elderly group (4.2%) due to cardiovascular disease. Significant differences were observed in the five-year OS and RFS rates of the elderly and non-elderly groups (55.4% vs. 29.7%, p=0.0017 and 42.2% vs. 21.2%, p=0.0334, respectively).
Although the rate of postoperative surgical complications after esophagectomy for esophageal cancer was almost equal in the elderly and the non-elderly patients, significant differences were observed in the mortality and long-term outcomes of the two groups. Thus, the surgical strategy and perioperative care must be carefully planned for esophageal cancer patients older than 75 years of age.
已经充分评估了 75 岁以上食管癌患者行食管癌切除术的短期和长期结果。
本研究纳入了行食管癌切除术的患者。患者分为非老年患者[年龄＜75 岁（非老年组）]和老年患者[年龄≥75 岁（老年组）]。评估非老年组和老年组之间的术后手术发病率、术后 30 天死亡率、无复发生存率（RFS）和总生存率（OS）。
本研究共评估了 122 例患者。98 例和 24 例患者分别归入非老年组和老年组。非老年组和老年组的术后手术并发症发生率分别为 71.4%和 75.0%。两组之间无统计学差异（p=0.710）。老年组有 1 例（4.2%）患者因心血管疾病死亡。老年组和非老年组的 5 年 OS 和 RFS 率有显著差异（55.4%比 29.7%，p=0.0017 和 42.2%比 21.2%，p=0.0334）。
尽管老年患者和非老年患者行食管癌切除术的术后手术并发症发生率几乎相同，但两组的死亡率和长期结果存在显著差异。因此，对于 75 岁以上的食管癌患者，必须仔细规划手术策略和围手术期护理。
