Department of Surgery, Yokohama City University, Yokohama, Japan
Department of Surgery, Yokohama City University, Yokohama, Japan.
In Vivo. 2020 Sep-Oct;34(5):2783-2790. doi: 10.21873/invivo.12103.
BACKGROUND/AIM: We investigated the impact of the age-adjusted Charlson comorbidity index (ACCI) on esophageal cancer survival and recurrence after curative treatment.
This study included 122 patients who underwent curative surgery followed by adjuvant chemotherapy for esophageal cancer between 2005 and 2017. The risk factors for the overall survival (OS) and recurrence-free survival (RFS) were identified.
An ACCI of 5 was regarded as the optimal critical point of classification considering the survival rates. The OS rates at 3 and 5 years after surgery were 64.2% and 54.4% in the low-ACCI group, respectively, and 42.3% and 29.2% in high-ACCI group, respectively (p=0.035). The RFS rates at 3 and 5 years after surgery were 50.2% and 43.6% in the low-ACCI group, respectively, and 28.5% and 21.3% in high-ACCI group, respectively (p=0.021). A multivariate analysis demonstrated that ACCI was a significant independent risk factor for both the OS and RFS.
ACCI is a risk factor for survival in patients who undergo curative treatment for esophageal cancer. An effective plan for the perioperative care and surgical strategy should be developed according to ACCI.
背景/目的：我们研究了年龄调整 Charlson 合并症指数 (ACCI) 对接受根治性治疗后食管癌生存和复发的影响。
本研究纳入了 122 例 2005 年至 2017 年间接受根治性手术和辅助化疗的食管癌患者。确定了总生存（OS）和无复发生存（RFS）的危险因素。
考虑到生存率，ACCI 为 5 被认为是分类的最佳临界点。低 ACCI 组术后 3 年和 5 年的 OS 率分别为 64.2%和 54.4%，高 ACCI 组分别为 42.3%和 29.2%（p=0.035）。低 ACCI 组术后 3 年和 5 年的 RFS 率分别为 50.2%和 43.6%，高 ACCI 组分别为 28.5%和 21.3%（p=0.021）。多变量分析表明，ACCI 是 OS 和 RFS 的独立危险因素。
ACCI 是接受食管癌根治性治疗患者生存的危险因素。应根据 ACCI 制定有效的围手术期护理和手术策略计划。
