老年食管鳞癌患者的管理。
Management of elderly patients with esophageal squamous cell cancer.
机构信息
Keio Cancer Center, Keio University Hospital, School of Medicine, Tokyo, Japan.
Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
出版信息
Jpn J Clin Oncol. 2022 Aug 5;52(8):816-824. doi: 10.1093/jjco/hyac067.
Abstract
This review focuses on the treatment about elderly esophageal cancer to clarify the current situation regarding our clinical question. Although there are several reviews about elderly esophageal cancer treatment, there are fundamental differences between Japan and the rest of the world. Two main differences are raised: histological differences and treatment strategies for resectable patients. We overview each status according to following clinical questions. First, there are no established evaluation criteria for frail. Second, selection criteria for surgery or non-surgery are not established. Third, few specific treatments for elderly patients (EPs) are investigated. In conclusion, there are many reports about treatment of esophageal squamous cell carcinoma for EPs, although treatment strategy is still controversial. We have to consider well-designed prospective trial to confirm specific treatment strategy according to each stage.
摘要
这篇综述重点关注老年食管癌的治疗，以阐明我们临床问题的现状。虽然有几篇关于老年食管癌治疗的综述，但日本与世界其他地区存在根本差异。主要有两个差异：组织学差异和可切除患者的治疗策略。我们根据以下临床问题综述了每种情况。首先，没有针对虚弱的既定评估标准。其次，手术或非手术的选择标准尚未确定。第三，针对老年患者（EP）的具体治疗方法研究较少。总之，尽管治疗策略仍存在争议，但有许多关于 EP 食管鳞癌治疗的报道。我们必须考虑进行精心设计的前瞻性试验，以根据每个阶段确定特定的治疗策略。
相似文献
1
Management of elderly patients with esophageal squamous cell cancer.老年食管鳞癌患者的管理。
Jpn J Clin Oncol. 2022 Aug 5;52(8):816-824. doi: 10.1093/jjco/hyac067.
2
Definitive chemoradiotherapy has comparable survival outcomes to esophagectomy in patients with clinical T1N0M0 esophageal squamous cell carcinoma: real-world data.对于临床 T1N0M0 期食管鳞癌患者，根治性放化疗与手术治疗的生存结局相当：真实世界数据。
Int J Clin Oncol. 2022 Aug;27(8):1279-1288. doi: 10.1007/s10147-022-02185-x. Epub 2022 Jul 2.
3
A phase-II/III randomized controlled trial of adjuvant radiotherapy or concurrent chemoradiotherapy after surgery versus surgery alone in patients with stage-IIB/III esophageal squamous cell carcinoma.一项 II/III 期随机对照临床试验，比较了手术后辅助放疗或同期放化疗与单纯手术治疗 IIB/III 期食管鳞癌患者的效果。
BMC Cancer. 2020 Feb 18;20(1):130. doi: 10.1186/s12885-020-6592-2.
4
Effectiveness of esophagectomy in patients with thoracic esophageal squamous cell carcinoma receiving definitive radiotherapy or concurrent chemoradiotherapy through intensity-modulated radiation therapy techniques.采用调强放射治疗技术对胸段食管鳞状细胞癌患者进行根治性放疗或同步放化疗后行食管切除术的疗效。
Cancer. 2017 Jun 1;123(11):2043-2053. doi: 10.1002/cncr.30565. Epub 2017 Feb 2.
5
CMISG1701: a multicenter prospective randomized phase III clinical trial comparing neoadjuvant chemoradiotherapy to neoadjuvant chemotherapy followed by minimally invasive esophagectomy in patients with locally advanced resectable esophageal squamous cell carcinoma (cTNM) (NCT03001596).CMISG1701：一项多中心前瞻性随机III期临床试验，比较新辅助放化疗与新辅助化疗后行微创食管切除术在局部晚期可切除食管鳞状细胞癌（cTNM）患者中的疗效（NCT03001596）。
BMC Cancer. 2017 Jun 28;17(1):450. doi: 10.1186/s12885-017-3446-7.
6
Comparison between surgery and definitive chemoradiotherapy for patients with resectable esophageal squamous cell carcinoma: a propensity score analysis.可切除食管鳞状细胞癌患者手术与根治性放化疗的比较：一项倾向评分分析
Int J Clin Oncol. 2016 Oct;21(5):890-898. doi: 10.1007/s10147-016-0963-3. Epub 2016 Mar 15.
7
Accuracy of detecting residual disease after neoadjuvant chemoradiotherapy for esophageal squamous cell carcinoma (preSINO trial): a prospective multicenter diagnostic cohort study.新辅助放化疗后检测食管鳞癌残留病灶的准确性（preSINO 试验）：一项前瞻性多中心诊断队列研究。
BMC Cancer. 2020 Mar 6;20(1):194. doi: 10.1186/s12885-020-6669-y.
8
Adjuvant therapy for pT1a-m3/pT1b esophageal squamous cell carcinoma after endoscopic resection: Esophagectomy or chemoradiotherapy? A critical review.内镜切除术后 pT1a-m3/pT1b 食管鳞癌的辅助治疗：食管切除术还是放化疗？批判性评价。
Crit Rev Oncol Hematol. 2020 Mar;147:102883. doi: 10.1016/j.critrevonc.2020.102883. Epub 2020 Jan 25.
9
Current Advancement in Multidisciplinary Treatment for Resectable cStage II/III Esophageal Squamous Cell Carcinoma in Japan.日本可切除的Ⅱ/Ⅲ期食管鳞状细胞癌多学科治疗的当前进展
Ann Thorac Cardiovasc Surg. 2016 Oct 20;22(5):275-283. doi: 10.5761/atcs.ra.16-00111. Epub 2016 Jul 6.
10
Chemoradiotherapy versus chemoradiotherapy plus surgery for esophageal cancer.食管癌的化疗放疗与化疗放疗联合手术治疗对比
Cochrane Database Syst Rev. 2017 Aug 22;8(8):CD010511. doi: 10.1002/14651858.CD010511.pub2.
引用本文的文献
1
Outcomes of Older Patients Undergoing Surgery for Esophageal Squamous Cell Carcinoma.老年食管鳞状细胞癌患者手术治疗的结果
In Vivo. 2025 Jul-Aug;39(4):2286-2294. doi: 10.21873/invivo.14024.
2
Feasibility and Safety of PD-1 Blockades Among Elderly Patients with Metastatic Esophageal Squamous Cell Carcinoma: A Real-World Study.老年转移性食管鳞癌患者使用 PD-1 阻断剂的可行性和安全性：一项真实世界研究。
Drug Des Devel Ther. 2024 Sep 16;18:4135-4151. doi: 10.2147/DDDT.S476457. eCollection 2024.
3
Definitive chemoradiotherapy with paclitaxel for locally advanced esophageal squamous cell carcinoma in older patients (PARADISE-1): a phase I trial.紫杉醇同步放化疗治疗老年局部晚期食管鳞癌（PARADISE-1）：一项 I 期临床试验。
BMC Cancer. 2024 Jul 19;24(1):873. doi: 10.1186/s12885-024-12653-4.
4
Survival Impacts of Impaired Lung Functions and Comorbidities on Elderly Esophageal Cancer Patients.肺功能障碍和合并症对老年食管癌患者生存的影响。
World J Surg. 2023 Dec;47(12):3229-3239. doi: 10.1007/s00268-023-07195-y. Epub 2023 Oct 6.
5
Real-world management and outcomes of older patients with locally advanced esophageal squamous cell carcinoma: a multicenter retrospective study.真实世界中老年局部晚期食管鳞癌患者的管理和结局：一项多中心回顾性研究。
BMC Cancer. 2023 Mar 28;23(1):283. doi: 10.1186/s12885-023-10710-y.
本文引用的文献
1
Comprehensive registry of esophageal cancer in Japan, 2014.日本 2014 年食管癌综合登记报告。
Esophagus. 2022 Jan;19(1):1-26. doi: 10.1007/s10388-021-00879-1. Epub 2021 Sep 22.
2
Pembrolizumab plus chemotherapy versus chemotherapy alone for first-line treatment of advanced oesophageal cancer (KEYNOTE-590): a randomised, placebo-controlled, phase 3 study.帕博利珠单抗联合化疗与单纯化疗一线治疗晚期食管癌（KEYNOTE-590）：一项随机、安慰剂对照、III 期研究。
Lancet. 2021 Aug 28;398(10302):759-771. doi: 10.1016/S0140-6736(21)01234-4.
3
Parallel-Group Controlled Trial of Surgery Versus Chemoradiotherapy in Patients With Stage I Esophageal Squamous Cell Carcinoma.Ⅰ 期食管鳞癌手术与放化疗的平行对照临床试验
Gastroenterology. 2021 Dec;161(6):1878-1886.e2. doi: 10.1053/j.gastro.2021.08.007. Epub 2021 Aug 10.
4
Efficacy of Concurrent Chemoradiotherapy With S-1 vs Radiotherapy Alone for Older Patients With Esophageal Cancer: A Multicenter Randomized Phase 3 Clinical Trial.替吉奥胶囊同步放化疗对比单纯放疗治疗老年食管癌患者的疗效：一项多中心随机 3 期临床试验。
JAMA Oncol. 2021 Oct 1;7(10):1459-1466. doi: 10.1001/jamaoncol.2021.2705.
5
Association of Sarcopenia With Toxicity and Survival in Postoperative Recurrent Esophageal Squamous Cell Carcinoma Patients Receiving Chemoradiotherapy.肌肉减少症与接受放化疗的术后复发性食管鳞状细胞癌患者毒性及生存的相关性
Front Oncol. 2021 Jul 8;11:655071. doi: 10.3389/fonc.2021.655071. eCollection 2021.
6
Changes in the quality of life score following preoperative chemotherapy in elderly patients with esophageal cancer.老年食管癌患者术前化疗后生活质量评分的变化。
Esophagus. 2022 Jan;19(1):113-119. doi: 10.1007/s10388-021-00862-w. Epub 2021 Jul 17.
7
The Impact of Preoperative Sarcopenia on Survival Prognosis in Patients Receiving Neoadjuvant Therapy for Esophageal Cancer: A Systematic Review and Meta-Analysis.术前肌肉减少症对接受食管癌新辅助治疗患者生存预后的影响：一项系统评价和荟萃分析
Front Oncol. 2021 Jun 23;11:619592. doi: 10.3389/fonc.2021.619592. eCollection 2021.
8
Phase I dose-escalation study of endoscopic intratumoral injection of OBP-301 (Telomelysin) with radiotherapy in oesophageal cancer patients unfit for standard treatments.OBP-301（端粒酶）经内镜瘤内注射联合放疗治疗不适合标准治疗的食管癌患者的 I 期剂量递增研究。
Eur J Cancer. 2021 Aug;153:98-108. doi: 10.1016/j.ejca.2021.04.043. Epub 2021 Jun 18.
9
Prognostic Significance of Preoperative Osteopenia in Patients Undergoing Esophagectomy for Esophageal Cancer.术前骨质疏松症对食管癌患者接受食管癌切除术的预后意义。
World J Surg. 2021 Oct;45(10):3119-3128. doi: 10.1007/s00268-021-06199-w. Epub 2021 Jun 21.
10
Esophageal Cancer in Elderly Patients, Current Treatment Options and Outcomes; A Systematic Review and Pooled Analysis.老年患者的食管癌：当前治疗选择与结果；系统评价与汇总分析
Cancers (Basel). 2021 Apr 27;13(9):2104. doi: 10.3390/cancers13092104.
Zotero 插件