Department of Neurosurgery, University Hospital Essen, Essen, Germany
German Cancer Consortium, Partner Site, University Hospital Essen, Essen, Germany.
Anticancer Res. 2020 Feb;40(2):1161-1166. doi: 10.21873/anticanres.14058.
Glioblastoma (GBM) is the most common malignant brain tumor in adults and still carries a dismal prognosis. As several studies detected a connection between inflammation and GBM prognosis, we sought to explore possible associations between routinely investigated inflammatory parameters and GBM outcome.
Patients treated for GBM at our Institution between 2004 and 2014 were included. White blood cell count (WBC), C-reactive protein (CRP) and the ratio of platelets and WBC (Plt/WBC) were evaluated preoperatively. Medical records were reviewed for clinical parameters (age, sex, preoperative clinical condition, genetic alterations). Study endpoints were overall (OS) and 1- and 2-year survival.
In the final cohort consisting of 565 individuals with GBM, univariate analysis showed significant associations for WBC, CRP and Plt/WBC ratio with OS. Kaplan-Meier survival plot confirmed significantly poorer OS in patients with WBC>12/nl and with CRP≥2.9 mg/dl. In multivariate analysis, a WBC of >12/nl was an independent prognostic factor for all three outcome parameters and CRP≥2.9 mg/dl for OS and 1-year survival.
Preoperative WBC and CRP values were confirmed as independent predictors of GBM outcome. This emphasizes the need for further evaluation of the role of inflammation in the prognosis of GBM.
胶质母细胞瘤（GBM）是成人中最常见的恶性脑肿瘤，预后仍然很差。由于几项研究检测到炎症与 GBM 预后之间存在联系，我们试图探讨常规研究的炎症参数与 GBM 结果之间的可能关联。
本研究纳入了 2004 年至 2014 年期间在我院接受 GBM 治疗的患者。术前评估白细胞计数（WBC）、C 反应蛋白（CRP）和血小板与 WBC 的比值（Plt/WBC）。回顾病历以获取临床参数（年龄、性别、术前临床状况、遗传改变）。研究终点为总生存期（OS）和 1 年及 2 年生存率。
在最终纳入的 565 名 GBM 患者队列中，单因素分析显示 WBC、CRP 和 Plt/WBC 比值与 OS 显著相关。Kaplan-Meier 生存图证实 WBC>12/nl 和 CRP≥2.9mg/dl 的患者 OS 显著更差。多因素分析显示，WBC>12/nl 是所有三个结局参数的独立预后因素，CRP≥2.9mg/dl 是 OS 和 1 年生存率的独立预后因素。
术前 WBC 和 CRP 值被确认为 GBM 结局的独立预测因子。这强调了需要进一步评估炎症在 GBM 预后中的作用。
