Department of Pharmacy, Cleveland Clinic; Genomic Medicine Institute, Lerner Research Institute, and Center for Personalized Genetic Healthcare, Cleveland Clinic Community Care
Clinical Assistant Professor, Department of Clinical Pharmacy, College of Pharmacy, University of Michigan; Department of Pharmacy, Michigan Medicine, Ann Arbor, MI.
Cleve Clin J Med. 2020 Feb;87(2):91-99. doi: 10.3949/ccjm.87a.19073.
Pharmacogenomics, ie, the study of how an individual's genomic profile influences his or her response to drugs, has emerged as a clinical tool to optimize drug therapy. Certain variants in some genes increase the risk of severe, life-threatening adverse effects from certain drugs. Integrating pharmacogenomics into clinical practice to assist in drug selection and dosing has the potential to improve the outcomes of treatment, reduce the risk of drug-induced morbidity and death, and be cost-effective.
药物基因组学，即研究个体基因组特征如何影响其对药物的反应，已成为优化药物治疗的临床工具。某些基因中的某些变体增加了某些药物引起严重、危及生命的不良反应的风险。将药物基因组学纳入临床实践，以协助药物选择和剂量调整，有可能改善治疗效果，降低药物引起的发病率和死亡率的风险，并具有成本效益。
