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Safety evaluation of intra-arterial cell delivery in stroke patients-a framework for future trials.

作者信息

Boltze Johannes, Jolkkonen Jukka

机构信息

School of Life Sciences, University of Warwick, Coventry, UK.

A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.

出版信息

Ann Transl Med. 2019 Dec;7(Suppl 8):S271. doi: 10.21037/atm.2019.12.07.

DOI:10.21037/atm.2019.12.07
PMID:32015990
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6976468/
Abstract
摘要

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Stem Cells as an Emerging Paradigm in Stroke 4: Advancing and Accelerating Preclinical Research.干细胞作为中风领域的新兴范例4：推进和加速临床前研究
Stroke. 2019 Nov;50(11):3299-3306. doi: 10.1161/STROKEAHA.119.025436. Epub 2019 Oct 17.
2
Cell therapy for ischemic stroke: Are differences in preclinical and clinical study design responsible for the translational loss of efficacy?缺血性中风的细胞治疗：临床前和临床研究设计的差异是否导致了疗效的转化损失？
Ann Neurol. 2019 Jul;86(1):5-16. doi: 10.1002/ana.25493. Epub 2019 May 8.
3
European Stroke Organisation guidelines for the management of post-stroke seizures and epilepsy.欧洲卒中组织关于卒中后癫痫发作和癫痫管理的指南。
Eur Stroke J. 2017 Jun;2(2):103-115. doi: 10.1177/2396987317705536. Epub 2017 Apr 19.
4
A Phase 2 Randomized, Sham-Controlled Trial of Internal Carotid Artery Infusion of Autologous Bone Marrow-Derived ALD-401 Cells in Patients With Recent Stable Ischemic Stroke (RECOVER-Stroke).一项自体骨髓源性 ALD-401 细胞经颈内动脉输注治疗近期稳定缺血性脑卒中患者的 2 期随机、假手术对照临床试验（RECOVER-Stroke）。
Circulation. 2019 Jan 8;139(2):192-205. doi: 10.1161/CIRCULATIONAHA.117.030659.
5
Safety and efficacy of multipotent adult progenitor cells in acute ischaemic stroke (MASTERS): a randomised, double-blind, placebo-controlled, phase 2 trial.多能成体祖细胞治疗急性缺血性脑卒中的安全性和有效性研究（MASTERS）：一项随机、双盲、安慰剂对照、2 期临床试验。
Lancet Neurol. 2017 May;16(5):360-368. doi: 10.1016/S1474-4422(17)30046-7. Epub 2017 Mar 17.
6
Real-time MRI for precise and predictable intra-arterial stem cell delivery to the central nervous system.用于精确且可预测地将动脉内干细胞输送到中枢神经系统的实时磁共振成像
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Stem Cells Int. 2016;2016:8657173. doi: 10.1155/2016/8657173. Epub 2016 Jul 21.
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Stroke. 2015 Aug;46(8):2354-63. doi: 10.1161/STROKEAHA.114.007803. Epub 2015 Jun 23.
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The cerebral embolism evoked by intra-arterial delivery of allogeneic bone marrow mesenchymal stem cells in rats is related to cell dose and infusion velocity.大鼠经动脉注射异体骨髓间充质干细胞诱发的脑栓塞与细胞剂量和输注速度有关。
Stem Cell Res Ther. 2015 Jan 27;6(1):11. doi: 10.1186/scrt544.