携带热不稳定肠毒素LT2基因新变体的O8:H8引发腹泻疫情。
O8:H8 Carrying a Novel Variant of the Heat-Labile Enterotoxin LT2 Gene Caused Outbreaks of Diarrhea.
作者信息
Ishimaru Kai, Sasaki Mari, Narimatsu Hiroshi, Arimizu Yoko, Gotoh Yasuhiro, Nakamura Keiji, Hayashi Tetsuya, Ogura Yoshitoshi
机构信息
Department of Bacteriology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
Section in Charge of Microbiology, Oita Prefectural Institute of Health and the Environment, Oita, Japan.
出版信息
Open Forum Infect Dis. 2020 Jan 14;7(1):ofaa021. doi: 10.1093/ofid/ofaa021. eCollection 2020 Jan.
No outbreaks caused by -producing heat-labile enterotoxin LT2 have been reported to date. Here, we revealed that the O8:H8 strains isolated from patients in 2 independent diarrhea outbreaks were negative for any known virulence determinants in routine microbiological tests, were very closely related, and carried a prophage-encoded gene for a novel LT2 variant (LT2d) and the genes for colonization factor antigen III. We also showed that LT2d has a cytotonic activity similar to LT1. These data indicate the importance of strains producing LT2d as a human pathogen.
迄今为止，尚未有由产生不耐热肠毒素LT2的菌株引起的疫情报告。在此，我们发现从2起独立腹泻疫情患者中分离出的O8:H8菌株在常规微生物检测中对任何已知毒力决定因素均呈阴性，它们密切相关，并携带一种新型LT2变体（LT2d）的前噬菌体编码基因以及定植因子抗原III的基因。我们还表明，LT2d具有与LT1相似的致细胞紧张活性。这些数据表明产生LT2d的菌株作为人类病原体的重要性。
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