铑(III)催化的烯丙基碳酸酯和苯并咪唑与氢气反应合成异喹啉衍生物。

Synthesis of rhodium(iii)-catalyzed isoquinoline derivatives from allyl carbonates and benzimidates with hydrogen evolution.

机构信息

Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.

出版信息

Org Biomol Chem. 2020 Feb 19;18(7):1412-1416. doi: 10.1039/c9ob02553g.

DOI:10.1039/c9ob02553g

PMID:32016247

Abstract

A novel Rh(iii)-catalyzed cascade C-H activation/cyclization approach to access isoquinoline derivatives from benzimidates and available allyl carbonates with the liberation of H2 has been realized. Allyl carbonates were first used as a versatile and universal C2 synthon to synthesize this biological activity skeleton via an efficient and practical process just within 1 h.

摘要

一种新型的 Rh(iii)-催化级联 C-H 活化/环化方法，可从苯并咪唑和易得的烯丙基碳酸酯中获得异喹啉衍生物，并释放出 H2。烯丙基碳酸酯首次被用作一种通用的 C2 合成子，通过高效实用的 1 小时反应过程，可用于合成具有生物活性的骨架。