钌（II）催化的 2-苯基吲哚与烯丙基碳酸酯的 C-H 烯丙基化串联氧化环化合成吲唑并[2,1-a]异喹啉。
Ruthenium(II)-Catalyzed Indolo[2,1-a]isoquinolines Synthesis by Tandem C-H Allylation and Oxidative Cyclization of 2-Phenylindoles with Allyl Carbonates.
机构信息
Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University , Chengdu 610041, China.
出版信息
Org Lett. 2017 May 5;19(9):2258-2261. doi: 10.1021/acs.orglett.7b00762. Epub 2017 Apr 17.
PMID:28414458
Abstract
A novel Ru-catalyzed tandem C-H bond activation tool has been successfully developed involving allylation and oxidative cyclization of 2-phenyl indoles with allyl carbonates. This one-pot reaction is a new way to synthesize indolo[2,1-a]isoquinoline units via a simple and efficient process.
摘要
一种新型的 Ru 催化串联 C-H 键活化工具已经成功开发，涉及烯丙基碳酸酯与 2-苯基吲哚的烯丙基化和氧化环化。这种一锅反应是通过简单有效的方法合成吲哚并[2,1-a]异喹啉单元的新途径。
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