Hou Jianbing, Cui Hongjuan
State Key Laboratory of Silkworm Genome Biology, Key Laboratory for Sericulture Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs, College of Biotechnology, Southwest University, Chongqing, China.
Cancer Center, Medical Research Institute, Southwest University, Chongqing, China.
Histol Histopathol. 2020 Jul;35(7):645-652. doi: 10.14670/HH-18-206. Epub 2020 Feb 4.
CSN6 has recently received increased attention as a multifunctional protein involved in protein stability. CSN6 plays an important role in controlling cellular proliferation, apoptosis and metastasis, modulating signal transduction, as well as regulating DNA damage and repair. Most studies have demonstrated that CSN6 is significantly upregulated in human malignant tumors such as cervical cancer, papillary thyroid cancer, colorectal cancer, breast cancer, lung adenocarcinoma, and glioblastoma, and its expression is usually correlated with poor prognosis. In this review, we summarize recent available findings regarding the oncogenic role of CSN6 in tumors, and provide a better understanding of CSN6 function at the molecular level and its potential therapeutic implications in combating human cancers.
CSN6作为一种参与蛋白质稳定性的多功能蛋白质，最近受到了越来越多的关注。CSN6在控制细胞增殖、凋亡和转移、调节信号转导以及调控DNA损伤和修复方面发挥着重要作用。大多数研究表明，CSN6在宫颈癌、甲状腺乳头状癌、结直肠癌、乳腺癌、肺腺癌和胶质母细胞瘤等人类恶性肿瘤中显著上调，其表达通常与不良预后相关。在本综述中，我们总结了关于CSN6在肿瘤中的致癌作用的最新研究结果，并在分子水平上更好地理解CSN6的功能及其在对抗人类癌症中的潜在治疗意义。
