Stem Cell and Regenerative Medicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
J Cell Physiol. 2020 Oct;235(10):6377-6392. doi: 10.1002/jcp.29616. Epub 2020 Feb 4.
Embryonic stem cells have potential differentiation ability into a large variety of cell lineages and proved to be an effective therapeutic modality. However, prolonged in vitro and ex-vivo expansions impair embryonic stem cells multipotentiality, and thereby limit their clinical application. In the past few years, research collected attempts to explore new insights into the molecular mechanisms participate in the stemness capacity of embryonic stem cells. Along with these comments, modalities and strategies with the potential to maintain embryonic stem cells multipotentiality are of great interest. In this review, the authors attempted to discuss the pathways participating in the preservation of embryonic stem cells multipotentiality and emphasized the novel strategies that help to harness regenerative potential.
胚胎干细胞具有向多种细胞谱系分化的潜能，并已被证明是一种有效的治疗方式。然而，体外和体外的长期扩增会损害胚胎干细胞的多能性，从而限制了它们的临床应用。在过去的几年中，研究人员试图探索新的见解，以探讨参与胚胎干细胞干性的分子机制。随着这些评论的出现，能够维持胚胎干细胞多能性的方式和策略引起了人们的极大兴趣。在这篇综述中，作者试图讨论参与胚胎干细胞多能性维持的途径，并强调有助于利用再生潜力的新策略。
