Su Wen, Guo Ruihua, Yuan Fanglong, Li Yunchao, Li Xiaohong, Zhang Yang, Zhou Shixin, Fan Louzhen
College of Chemistry, Key Laboratory of Theoretical & Computational Photochemistry, and Radiopharmaceuticals, Ministry of Education , Beijing Normal University , Beijing 100875 , China.
Department of Cell Biology, School of Basic Medicine , Peking University Health Science Center , Beijing 100191 , China.
J Phys Chem Lett. 2020 Feb 20;11(4):1357-1363. doi: 10.1021/acs.jpclett.9b03891. Epub 2020 Feb 4.
Large doses of anticancer drugs entering cancer cell nuclei are found to be effective at killing cancer cells and increasing chemotherapeutic effectiveness. Here we report red-emissive carbon quantum dots, which can enter into the nuclei of not only cancer cells but also cancer stem cells. After doxorubicin was loaded at the concentration of 30 μg/mL on the surfaces of carbon quantum dots, the average cell viability of HeLa cells was decreased to only 21%, while it was decreased to 50% for free doxorubicin. The doxorubicin-loaded carbon quantum dots also exhibited a good therapeutic effect by eliminating cancer stem cells. This work provides a potential strategy for developing carbon quantum-dot-based anticancer drug carriers for effective eradication of cancers.
研究发现，大量进入癌细胞核的抗癌药物在杀死癌细胞和提高化疗效果方面具有成效。在此，我们报告了发红光的碳量子点，其不仅可以进入癌细胞的细胞核，还能进入癌症干细胞的细胞核。当以30μg/mL的浓度将阿霉素负载在碳量子点表面后，HeLa细胞的平均细胞活力仅降至21%，而游离阿霉素使其降至50%。负载阿霉素的碳量子点在消除癌症干细胞方面也表现出良好的治疗效果。这项工作为开发基于碳量子点的抗癌药物载体以有效根除癌症提供了一种潜在策略。
