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碳量子点在癌症治疗中的近期生物医学应用

Recent Biomedical Applications of Carbon Quantum Dots in Cancer Treatment.

作者信息

Mowery Jenna L, Chen Jixin

机构信息

Department of Chemistry and Biochemistry, Nanoscale & Quantum Phenomena Institute, Ohio University, Athens, Ohio 45701, United States.

出版信息

J Phys Chem C Nanomater Interfaces. 2024 Oct 3;128(39):16291-16301. doi: 10.1021/acs.jpcc.4c04847. Epub 2024 Sep 20.

DOI:10.1021/acs.jpcc.4c04847
PMID:40927338
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12416908/
Abstract

Carbon-based quantum dots (CQDs) have been around for a few decades. Low cell toxicity, good water solubility, excellent and tunable fluorescence properties, and the ability to dope and modify the surface of these CQDs make them an incredible choice for the visualization and treatment of various cancers. This perspective analyzes some recent progress on size-color correlation, modification, and cancer treatment applications of CQDs. Synthesis and modification of CQDs to make them more efficient and more biocompatible are essential to their bioapplications.

摘要

碳基量子点(CQDs)已经存在了几十年。低细胞毒性、良好的水溶性、优异且可调节的荧光特性,以及对这些CQDs进行掺杂和表面修饰的能力,使其成为可视化和治疗各种癌症的绝佳选择。本文综述了CQDs在尺寸-颜色相关性、修饰以及癌症治疗应用方面的一些最新进展。对CQDs进行合成和修饰以使其更高效、更具生物相容性,对其生物应用至关重要。

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本文引用的文献

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Photoinduced Electron Transfer between Dipolar Reactants: Solvent and Excitation Wavelength Effects.偶极反应物之间的光致电子转移:溶剂和激发波长效应
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基于碳基量子点的肿瘤诊断:基于癌症特征的检测
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Progress on the luminescence mechanism and application of carbon quantum dots based on biomass synthesis.基于生物质合成的碳量子点发光机制及其应用研究进展
RSC Adv. 2023 Jun 23;13(28):19173-19194. doi: 10.1039/d3ra02519e. eCollection 2023 Jun 22.
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Nanoparticles in Clinical Trials: Analysis of Clinical Trials, FDA Approvals and Use for COVID-19 Vaccines.临床试验中的纳米颗粒:临床试验分析、FDA 批准情况以及在 COVID-19 疫苗中的应用。
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One-Step Colloidal Synthesis of Non-Toxic Electroactive Carbon Dots with a Better Threshold Cytotoxicity and Cytocompatibility.一步法胶体合成具有更好阈值细胞毒性和细胞相容性的无毒电活性碳点
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Nitrogen and sulphur doped carbon dot: An excellent biocompatible candidate for in-vitro cancer cell imaging and beyond.氮硫共掺杂碳点:用于体外癌细胞成像及其他应用的优异生物相容性候选材料。
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Preparation of a pH-responsive chitosan-montmorillonite-nitrogen-doped carbon quantum dots nanocarrier for attenuating doxorubicin limitations in cancer therapy.用于减轻阿霉素在癌症治疗中局限性的pH响应性壳聚糖-蒙脱石-氮掺杂碳量子点纳米载体的制备
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9
Investigating the effect of N-doping on carbon quantum dots structure, optical properties and metal ion screening.研究 N 掺杂对碳量子点结构、光学性质和金属离子筛选的影响。
Sci Rep. 2022 Aug 15;12(1):13806. doi: 10.1038/s41598-022-16893-x.
10
State-of-the-art developments in carbon quantum dots (CQDs): Photo-catalysis, bio-imaging, and bio-sensing applications.碳量子点的最新发展:光催化、生物成像和生物传感应用。
Chemosphere. 2022 Sep;302:134815. doi: 10.1016/j.chemosphere.2022.134815. Epub 2022 May 5.