Wali Adil Farooq, Pillai Jayachithra Ramakrishna, Al Dhaheri Yusra, Rehman Muneeb U, Shoaib Ambreen, Sarheed Omar, Jabnoun Salma, Razmpoor Maryam, Rasool Saiema, Paray Bilal Ahmad, Ahmad Parvaiz
Department of Pharmaceutical Chemistry, RAKCOPS, RAK Medical and Health Sciences University, Ras Al Khaimah 11172, UAE.
Department of Biology, College of Science, United Arab Emirates University, Al Ain 15551, UAE.
Plants (Basel). 2020 Jan 30;9(2):167. doi: 10.3390/plants9020167.
The purpose of this study is to analyze the polyphenolic rich extract of L. petals (CSP) in modulating liver oxidative stress and inflammatory response status against rifampicin isoniazid (INH-RIF) drug-induced liver injury. The INH-RIF was administered for 14 days with varying doses in Wistar rats, while silymarin was administered as standard dose. We report the defensive impacts of CSP against INH-RIF induced liver oxidative stress and proinflammatory cytokine. The CSP treatment at both doses significantly controlled all modulating biochemical hepatic injury indicators and resulted in the attenuation of arbitral INH-RIF damage. The components present in CSP identified by LC-ESI-Q-TOF-MS were found to be flavonoids and fatty acids. It can be inferred that CSP possesses a hepatoprotective capacity against INH-RIF-mediated hepatic injury, which may prove to be a medically beneficial natural product for the management of drug-induced liver injury.
本研究的目的是分析石榴花瓣富含多酚的提取物（CSP）在调节肝脏氧化应激和针对利福平异烟肼（INH-RIF）药物性肝损伤的炎症反应状态方面的作用。在Wistar大鼠中以不同剂量给予INH-RIF 14天，同时以标准剂量给予水飞蓟宾。我们报告了CSP对INH-RIF诱导的肝脏氧化应激和促炎细胞因子的防御作用。两种剂量的CSP处理均显著控制了所有调节肝脏生化损伤的指标，并减轻了INH-RIF造成的任意损伤。通过LC-ESI-Q-TOF-MS鉴定出CSP中存在的成分是黄酮类化合物和脂肪酸。可以推断，CSP对INH-RIF介导的肝损伤具有肝脏保护能力，这可能被证明是一种对药物性肝损伤管理具有医学益处的天然产物。
