University Hospital of Ioannina, Ioannina, Greece.
North Hospital, University Hospital of St-Etienne, St-Etienne, France.
Int J Surg Pathol. 2020 Aug;28(5):496-501. doi: 10.1177/1066896920904423. Epub 2020 Feb 5.
White adipose tissue browning has emerged as a putative therapy of obesity, and studies in mice have shown that is implicated in white-to-brown transition. However, the role of product p16 has been never studied in human brown fat tissue. The aim of the study is to investigate the expression of p16 in normal brown fat and in hibernoma, a lipoma containing brown fat-like adipocytes. Ten normal brown fat tissues and 5 hibernomas were immunohistochemically studied for p16 expression. Nearby white adipose tissue was used for comparison. All brown fat and hibernomas specimens express p16 in a cytoplasmic manner. Neighboring white adipose tissue is negative for p16 expression. Thus, cytoplasmic p16 may be associated with fat tissue browning.
白色脂肪组织棕色化已成为肥胖治疗的一种可能方法，并且小鼠研究表明 参与白色向棕色的转变。然而， 产物 p16 在人类棕色脂肪组织中的作用从未被研究过。本研究旨在探讨 p16 在正常棕色脂肪组织和冬眠瘤（一种含有棕色脂肪样脂肪细胞的脂肪瘤）中的表达。对 10 份正常棕色脂肪组织和 5 份冬眠瘤进行了 p16 表达的免疫组织化学研究。同时使用附近的白色脂肪组织作为对照。所有棕色脂肪组织和冬眠瘤标本均以细胞质方式表达 p16。邻近的白色脂肪组织则不表达 p16。因此，细胞质 p16 可能与脂肪组织棕色化有关。
