冬眠瘤：棕色脂肪组织发生的一种可能模型。

Hibernoma: a possible model of brown fat histogenesis.

作者信息

Dardick I

出版信息

Hum Pathol. 1978 May;9(3):321-9. doi: 10.1016/s0046-8177(78)80089-6.

Abstract

Hibernomas are composed of cells remarkably similar to those observed in brown adipose tissue. A surgically resected hibernoma was observed to contain cells at all stages of maturation from immature, relatively lipid free cells to multiloculated and finally uniloculated adipocytes. The ultrastructural features of adipocytes contained in the hibernoma were compared to previously reported features of differentiating preadipocytes and lipid depleted mature adipocytes derived from human white adipose tissue. This comparison confirmed the existence of distinct mitochondrial and cytoplasmic membrane component differences at all developmental stages and suggests that brown and white adipose tissue are two unique histologic types.

摘要

冬眠瘤由与棕色脂肪组织中观察到的细胞非常相似的细胞组成。一个手术切除的冬眠瘤被观察到含有从不成熟、相对无脂质的细胞到多房性以及最终单房性脂肪细胞的所有成熟阶段的细胞。将冬眠瘤中所含脂肪细胞的超微结构特征与先前报道的源自人白色脂肪组织的分化前脂肪细胞和脂质耗尽的成熟脂肪细胞的特征进行了比较。这种比较证实了在所有发育阶段存在明显的线粒体和细胞质膜成分差异，并表明棕色和白色脂肪组织是两种独特的组织学类型。